Chemicals, Bottle, Glass, Clear
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4-Thiouridine
Cayman ChemicalA photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling.
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N-Decanoyl p-Nitroaniline
Cayman ChemicalDepNA is one of several nitroaniline fatty acid amides which can be used to measure FAAH activity.{8928} FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its endogenous substrate AEA. It also will hydrolyze fatty acid amides…
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a-Amanitin
Cayman ChemicalA mycotoxin that selectively inhibits RNA polymerase II (1 µg/ml), preventing translocation of the enzymes on DNA; used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.
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(S)-Naproxen
Cayman Chemical(S)-Naproxen is a non-selective COX inhibitor. The IC50 values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively.
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Microcystin-RR
Cayman ChemicalA toxin produced by cyanobacteria that inhibits the catalytic activity of protein phosphatases PP1C, PP1γ, and PP2A with Ki values of 0.15, 0.24, and 0.018 nM, respectively.
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Spiro-MeOTAD
Cayman ChemicalA stable and efficient hole-transport material in organic light-emitting devices and in ssDSSCs; yields high ssDSSC efficiency due to its excellent pore-filling property into mesoporous titania films.
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ML-277
Cayman ChemicalA potent activator of KCNQ1 (Kv7.1) channels (EC50 = 260 nM); EC50 > 30 µM for KCNQ2, KCNQ4, and hERG; potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments IKs current in cultured…
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Iberin
Cayman ChemicalA natural isothiocyanate which induces the expression of phase II detoxification enzymes and activates Nrf2, promoting the expression of antioxidant and phase II genes; acts as a quorum sensing inhibitor, blocking acyl-homoserine lactone signaling in P. aeruginosa without affecting growth…
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Prostaglandin F2ß (tromethamine salt)
Cayman ChemicalA derivative of PGF2β with increased water solubility.
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12-OAHSA
Cayman ChemicalA FAHFA in which oleic acid occurs at the 12-position on hydroxy stearic acid.
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Luminol
Cayman ChemicalA cyclic diacyl hydrazide that exhibits chemiluminescence upon oxidation; HRP combined with H2O2 causes luminescent peroxidation of luminol; can also be oxidized, and chemiluminesce, by compounds containing iron, copper, gold, and cyanide.
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Caspase-3 Inhibitor VII
Cayman ChemicalCAS Number: 745046-84-8 Synonyms: Ivachtin Molecular Formula: C20H21N3O7S
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16(R)-HETE
Cayman ChemicalA minor CYP450 metabolite of arachidonic acid that stimulates vasodilation of rabbit kidney.
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FCCP
Cayman ChemicalA potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes.
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PD 153035 (hydrochloride)
Cayman ChemicalA highly potent, reversible inhibitor of the EGFR (Ki = 5.2 pM; IC50 = 29 pM); rapidly suppresses autophosphorylation of EGFR in ?broblasts and human epidermoid carcinoma cells.
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Nital, 18% Nitric Acid (w/w), Volumetric
Reagents®Concentration: 18% w/w in Methanol Composition: Methyl Alcohol 82%, Nitric Acid 12.60%, Water 5.40% Boiling Point: Approximately 64°C Density: 0.9 Melting Point: Color: Colorless to light yellow liquid Physical State: Liquid Flash Point: 16°C pH Range: Solubility Information:…
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4-Methylumbelliferyl-ß-D-Glucuronide (hydrate)
Cayman ChemicalA fluorogenic substrate of β-glucuronidase that upon cleavage yields a blue fluorescent end product that can be monitored by UV light; typically used in the GUS reporter system for fluorescent detection of β-glucuronidase gene expression in E. coli and transformed plants.
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a-Truxillic Acid
Cayman ChemicalCan be formed by the dimerization of two molecules of α-trans-cinnamic acid; significantly blocks inflammatory pain while having little effect on neurogenic pain, as indicated by the formalin test in mice.
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Lutein
Cayman ChemicalA natural yellow carotenoid, which can be found in plants, egg yolks, and in the human retina; a lipid-soluble antioxidant that can circulate in the plasma and confer cardioprotective, anti-inflammatory, and anti-angiogenic effects.
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Etoricoxib
Cayman ChemicalA dipyridinyl compound that demonstrates high in vitro and ex vivo selectivity for COX-2 over COX-1.
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Prostaglandin B1
Cayman ChemicalPGB1 is a non-enzymatic dehydration product of PGE1 resulting from treatment with strong base. Oligomers of PGB1 are known to exhibit antioxidant and ionophoric activity.
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Brefeldin A
Cayman ChemicalA natural fungal metabolite which reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum; directly and reversibly inhibits Sec7 domain-containing GEFs which are necessary for Arf activation associated with vesicular transport (IC50 =…
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Hygromycin B
Cayman ChemicalAn antibiotic which is used in molecular and cell biology to select for transformed cells expressing the hygromycin resistance gene; kills prokaryotic and eukaryotic cells by inhibiting protein synthesis.
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Medetomidine (hydrochloride)
Cayman ChemicalA selective agonist of α2-adrenoceptors (Ki = 1.08 nM vs. 1750 nM for α1-adrenoceptors) that has sedative, antinociceptive, analgesic, and hypothermic actions; additive or synergistic with fentanyl-type opioids in reducing pain; has anesthetic sparing properties.
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4-hydroxy Nonenal Mercapturic Acid-d3
Cayman ChemicalAn internal standard for the quantification of 4-HNE mercapturic acid by GC- or LC-MS.
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Actinomycin D
Cayman ChemicalA cyclic polypeptide-containing anticancer antibiotic that binds to DNA and blocks transcription by interfering with RNA synthesis; ~10 nM promotes cell death in a variety of tumors.
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Cytochalasin B
Cayman ChemicalA cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments; blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis, and glucose transport.
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Olaparib
Cayman ChemicalA potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 µM); can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.
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17-phenyl trinor Prostaglandin F2a diethyl amide
Cayman ChemicalAn F-series PG analog in which the C-1 carboxyl group has been modified to an N-diethyl amide; dialkyl amides such as a 17-p-PGF2α-NEt2 are inert to corneal amidase activity, and are not converted in any detectable amount to the corresponding free acids.
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Brevetoxin B
Cayman ChemicalA neurotoxin that binds to voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively; ichthyotoxic at nanomolar concentrations.
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Salinomycin (sodium salt)
Cayman ChemicalAn antibacterial and coccidiostat compound that shows selective toxicity for HMLER breast cancer stem cells (IC50 = ~24 μM); 8 μM treatment of 4T1 and MCF-7-Ras breast cancer cell lines decreases cancer stem cell growth ~2-fold and ~3-fold, respectively; 5 mg/kg inhibits mammary…