16,16-dimethyl PGF2β is a metabolically stable analog of PGF2β. It prevents bronchospasm in asthmatics but is less potent than PGE2.

A potent, selective, and orally bioavailable inhibitor of PRMT5 (Ki = 5 nM); blocks the growth of mantle cell lymphoma Z-138 xenografts, without significant body weight loss, in mice.

A potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 94 nM), ALK4 (IC₅₀ = 140 nM) and, less effectively, ALK7; suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.

A major component of the root of P. suffruiticosa that at 30 µM inhibits the growth of human hepatocellular carcinoma SK-HEP-1 cells by causing cell cycle arrest and suppressing the activation of NF-κB.

A potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC₅₀ values of 67 and 289 nM for the human and rat isoforms, respectively; attenuates cold allodynia following nerve injury and suppresses neuronal activity in response to mechanical stimulation.

Synonym(s): (±)-MVA-Li; rac. -MVA-Li; Lithium (±)-3,5-dihydroxy-3-methyl-pentanoate; Lithium (±)-3,5-dihydroxy-3-methyl-valerate Empirical Formula: C₆H₁₁O₄ -+ xLi + Linear Formula: C₆H₁₁O₄ -+ xLi + …

Empirical Formula: C₆H₁₄NO₈P Linear Formula: C₆H₁₄NO₈P Formula Weight: 259.15 MDL Number: MFCD00067382 Purity: ≥98% Storage: −20°C

Calcitriol is synthesized from 7-dehydrocholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy Vitamin D3, the principal circulating form of Vitamin D. A second, tightly…

Produced and qualified by HWI pharma services GmbH.Exact content by quantitative NMR can be found on the certificate. Synonyms: (1R,3R,6S)-2,2,6,8-Tetramethyltricyclo[5.3.1.03,8]undec-3-ol Molecular Formula: C15H26O Molecular Weight: 222.37 Linear Structural Formula: C15H26O MDL…

Formula: C₁₂H₁₄N₄·4HCl   Formula Weight: 360.12   CAS #: 7411-49-6 Melting Point: 300°C Used for histochemical localization of peroxidase with DAB and in immunocytochemistry. Sternberger, et.al., J. Histochem,…

A potent inhibitor that blocks dopamine uptake (IC₅₀ = 1-51 nM); effectively inhibits dopamine uptake in vivo, leading to consequent stimulation of dopamine receptors.

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG Synonyms: Sinapic acid choline ester chloride …

Synonyms: trans -(±)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3 H )-quinazolinone monohydrobromide Formula: C₁₆H₁₇BrClN₃O₃ · HBr Formula Weight: 495.59 CAS No.: 64924-67-0 Legal Information: VETRANAL is a…

A reversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase; blocks H2S synthesis in rat liver preparations with an IC50 value of 6.5 µM.

Inhibits ALK5- (IC50 = 47 nM), ALK4- (IC50 = 129 nM), and ALK7-dependent activation of downstream SMAD2 and SMAD3 and TGF-β–induced MAP kinase pathway components without altering ALK1-3 or ALK6-induced SMAD signaling.

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG Synonyms: …

Synonym(s): HAT Inhibitor IV, Gcn5p Inhibitor Formula: C14H14ClN3S Formula weight: 291.80 CAS Number: 357649-93-5 Harmonized Tariff Code:  2934.10

A calcimimetic compound that can allosterically activate or positively modulate the human CaSR; dose-dependently decreases circulating levels of PTH in both normal individuals and patients with primary hyperparathyroidism in clinical trials.

An inhibitor of HIF-1α protein translation; suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase; cytotoxic to a variety of cancer cell lines with an IC₅₀ value of 15-25 µM.

A broad spectrum antibiotic that is in the β-lactam subclass known as carbapenems; effective against many Gram-negative and Gram-positive bacteria and is more effective against P. aeruginosa than other carbapenems; not effective against MSRA.

CAS No.: 1180-71-8 Synonyms: Limonoic acid 3,19:16,17 dilactone Formula: C₂₆H₃₀O₈ Formula Weight: 470.51 Linear Formula: C₂₆H₃₀O₈ MDL No.: MFCD00075922 Purity: ≥90.0% (HPLC)

A cell permeable analog of BAPTA that binds calcium only after the AM group is removed by cytoplasmic esterases; commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling; also inhibits Kv channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30…

Raclopride is a selective dopamine D₂/D₃ receptor antagonist with K_i values of 1.8, 3.5, 2,400, and 18,000 nM for D₂, D₃, D₄, and D₁ receptors, respectively. It passes the blood brain barrier and can be used in in vivo…

CAS No.: 14216-03-6 Formula: C₅₉H₉₆O₂₆ Formula Weight: 1221.38 Linear Formula: C₅₉H₉₆O₂₆ MDL No.: MFCD00198062 Melting Point: 222 °C (dec.)(lit.)

A selective, nonpeptide AT2R antagonist (IC₅₀ = 5.6 nM vs. 100 nM for AT1R) that has been used to selectively examine the specific roles for AT1R and AT2R in hypertensive and other vascular research-related models.

A potent inhibitor of 15-PGDH (Ki = ~0.1 nM) that has activity in vivo; rapidly increases the levels of PGE2 in bone marrow and other tissues in mice after intraperitoneal injection.

A reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC₅₀ = 0.65 and 0.58 nM, respectively); stimulates glycogen synthase in cells (EC₅₀ = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in…

A potent and selective inhibitor of PLD1, both in vitro (IC₅₀ = 46 nM) and in cells (IC₅₀ = 11 nM); also effective as a PLD2 inhibitor at higher concentrations (IC₅₀ = 933 nM in vitro; 1,800 nM in cells); strongly inhibits the invasive migration of several breast…

A partial receptor agonist of mGlu4, effective at 100 µM, with no activity at other mGlu receptor subtypes; induces apoptosis of T cells at 300-500 µM.

A selective inhibitor of PAD4 (IC₅₀ = 200 nM in the absence of calicum); inhibits the citrullination of PAD4 target proteins and diminishes NET formation in mouse neutrophils.

An antagonist of CXCR4, blocking CXCR4-mediated HIV infection with an IC50 value of 19.3 nM; at 100 μg/ml, inhibits CXCL12-induced phosphorylation of p42/44 MAPK and STAT3; activates CXCR7 (EC50 = 350 nM), resulting in the recruitment of β-arrestin and Erk ½ phosphorylation.