Chemicals, Cayman Chemical
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Manumycin A
Cayman ChemicalA potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity: inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation; inhibits IKK in an number of cells types.
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DBeQ
Cayman ChemicalA selective, reversible, and ATP-competitive inhibitor of the ATPase p97 (Ki = 3.2 μM; IC50 = 1.5 μM); blocks endoplasmic reticulum-associated degradation, impairing the autophagy pathway and promoting the activation of caspase-3 and -7 in cancer cells.
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Bicuculline
Cayman ChemicalA competitive GABAA receptor antagonist that at 100 μM blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons; reversibly blocks GABAA receptors on horizontal cells in the mouse retina (IC50 = 1.7 μM); mimics the action of epilepsy and…
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A-967079
Cayman ChemicalA potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively; attenuates cold allodynia following nerve injury and suppresses neuronal activity in response to mechanical stimulation.
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Lucigenin
Cayman ChemicalA dual purpose probe; a chemiluminescent probe that detects superoxide production by enzymatic and cellular sources; a fluorescent chloride-sensitive indicator, with fluorescence being quenched by chloride (excitation: 455 nm; emission: 505 nm).
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Omeprazole
Cayman ChemicalA selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC50 = 1.1 μM).
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Harringtonine
Cayman ChemicalA natural alkaloid that inhibits protein synthesis at low micromolar concentrations; immobilizes ribosomes immediately after the initiation of translation.
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Sunitinib Malate
Cayman ChemicalA small molecule, multi-targeted receptor tyrosine kinase inhibitor; potently inhibits signaling through PDGFR, VEGFR, KIT, and FLT3; inhibits both tumor cell growth and angiogenesis; approved by the FDA for the treatment of gastrointestinal stromal tumor and metastatic renal cell carcinoma.
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NADPH (sodium salt)
Cayman ChemicalThe reduced form of the electron acceptor NADP+ and acts as an electron donor in various biological reactions.
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Oligomycin A
Cayman ChemicalAn inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types (average GI50 = 270 nM); exhibits antifungal, antitumor, and nematocidal activities, but has poor solubility in water and other biocompatible solvents.
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Guanylate Cyclase a subunit (soluble) Blocking Peptide
Cayman ChemicalPeptide sequences: human guanylate cyclase α subunit amino acids 418-436 (EQARAQDGLKKRLGKLKAT) To be used in conjunction with Cayman’s guanylate cyclase α subunit polyclonal antibody (Catalog No. 160895) to block protein-antibody complex formation during analysis for guanylate…
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Diallyl Trisulfide
Cayman ChemicalAn organic polysulfide compound found in garlic that acts as an H2S donor; reduces the survival of prostate cancer PC-3 cells (IC50 = 22 μM) and inhibits the growth of human colon adenocarcinoma HCT15 cells (IC50 = 11.5 μM); suppresses the growth of PC-3 xenografts in vivo in mice and induces…
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Romidepsin
Cayman ChemicalA natural bicyclic depsipeptide that, following reduction, selectively inhibits class I HDACs (IC50s = 53, 39, 53, and 26 nM, for HDACs 1, 2, 3, and 8, respectively); has anti-cancer activities, particularly against certain T cell lymphomas.
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Anti-Citrullinated Human Fibrinogen Assay Kit (mouse)
Cayman ChemicalImmunization of mice with citrullinated human fibrinogen, especially mice expressing the human HLA-DR4 transgene, induces an arthritic response driven by the production of antibodies that recognize citrullinated epitopes. The polyclonal antibody response produces antibodies reactive with both…
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Fludarabine
Cayman ChemicalA nuclesoside analog that disrupts DNA synthesis in blood cells; effective in a number of animal tumor systems including LI210 leukemia, CD8F mammary adenocarcinoma, P388 leukemia, and human LX-1 lung tumor xenograft and displays anticancer activity against human hematological malignancies in vivo.
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Prostaglandin F2a-d4
Cayman ChemicalAn internal standard for the quantification of PGF2α by GC- or LC-MS.
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ß-Nicotinamide Mononucleotide
Cayman ChemicalAn intermediate in the biosynthesis of NAD+ that has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in Nampt+/- mice and high-fat diet-induced type 2 diabetes mice.
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Exendin-4 (acetate)
Cayman ChemicalA potent peptide agonist of the GLP-1 receptor (Ki = 136 pM); stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells, supporting efficacy in type 2 diabetes; protects hippocampal neurons against glutamate-induced apoptosis.
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PDMP (hydrochloride)
Cayman ChemicalA ceramide analog that contains a mixture of all four possible stereoisomers.
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A-23187
Cayman ChemicalA divalent cation ionophore, commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways; also used to produce apoptosis through calcium overload, as occurs during hypoxic or oxidative stress.
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Eprosartan (mesylate)
Cayman ChemicalA competitive AT1 receptor antagonist (IC50s 1.4 – 3.9 nM and an elimination half-life of 5 to 7 hours) that blocks angiotensin II receptors on both sympathetic nerve terminals and blood vessels.
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Trolox
Cayman ChemicalA cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties; commonly used as a standard or positive control in antioxidant assays.
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MK-2206 (hydrochloride)
Cayman ChemicalAn orally active, allosteric Akt inhibitor (IC50s = 5, 12, and 65 nM for Akt1, 2, and 3, respectively); inhibits cell proliferation of human cancer cell lines synergistically in combination with other topoisomerase inhibitors, antimetabolites, antimicrotubule agents, DNA cross-linkers or growth…
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Vinclozolin M2
Cayman ChemicalA metabolite of vinclozolin, a dicarboximide fungicide, that acts as an effective antagonist of the androgen receptor (Ki = 9.7 µM in rat).
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CZC 54252
Cayman ChemicalCZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50s = 1.28 and 1.85 nM for wild-type and G2019S mutant forms of LRRK2, respectively). It has been shown to protect against neuronal injury induced by Parkinson’s disease-related LRRK2-G2019S mutant activity in…
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Protein Synthesis Assay Kit
Cayman ChemicalCayman’s Protein Synthesis Assay Kit is a non-radioactive method for measuring protein synthesis that employs the cell-permeable, alkyne-containing, puromycin analog O-Propargyl-puromycin (OPP). Upon application to cells, the OPP probe incorporates into the C-terminus of translating…
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TMRE Mitochondrial Membrane Potential Assay Kit
Cayman ChemicalCayman’s TMRE Mitochondrial Membrane Potential Assay Kit utilizes tetramethylrhodamine ethyl ester (TMRE), a cell permeable, cationic dye which accumulates in the mitochondrial matrix based on mitochondrial membrane potential (ΔψM). This assay, which is suitable for high-throughput…
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1-thio-ß-D-Glucose (sodium salt)
Cayman ChemicalAn analog of β-D-glucose in which sulfur replaces the hydroxyl group at the one position, allowing diverse chemical reactions, including click chemistry and polymerization; can be labeled with technetium-99m for analytical and diagnostic procedures.
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Dihydrodaidzein
Cayman ChemicalAn active, estrogenic metabolite of daidzein; has vasodilatory action on rat isolated aortic rings at 1 µg/ml; stimulates the estrogen receptor-dependent growth of breast cancer MCF-7 cells at micromolar concentrations.
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Ursolic Acid
Cayman ChemicalA natural triterpenoid carboxylic acid that is known to have antioxidative, antimicrobial, anti-inflammatory, and anticancer activities; inhibits Na+/K+-ATPase activity (IC50 = 24.7 μM) and blocks NF-κB activation in various human cancer cells lines (10-100 μM), inhibiting cell…
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L-myo-Inositol-1,4,5-triphosphate (sodium salt)
Cayman ChemicalThe L isomer of the biologically important D-myo-inositol-1,4,5-triphosphate; does not evoke a rise in intracellular calcium when added to cells.