Protein, 100 µg
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FABP2 (rat recombinant)
Cayman ChemicalSource: recombinant N-terminal hexahistidine-tagged protein expressed in E. coli Mr: 19.3 kDa Protein concentration: 1.0 mg/ml
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PPARa LBD (human recombinant)
Cayman ChemicalSource: recombinant His-tagged protein purified from E. coli Mr: ~34 kDa PPARα transcriptionally regulates a variety of genes involved in fatty acid metabolism and oxidation, such as acyl-CoA oxidase, enol-CoA hydratase, medium chain fatty acyl-CoA dehydrogenase, fatty acid transport…
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CREB-binding protein bromodomain (human recombinant)
Cayman ChemicalSource: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 40.8 kDa CREBBP bromodomain has been shown to modulate the stability and function of the tumor suppressor protein p53. CREBBP bromodomain recognizes the acetylated lysine residue 382 on p53.
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Irisin (human recombinant)
Cayman ChemicalSource: recombinant protein expressed in E. coli. An N-terminal His-tag and SUMOpro tag were removed by cleavage with SUMO protease 1 (Ulp1). Mr: 12.4 kDa
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BRD2 bromodomains 1 and 2 (human recombinant)
Cayman ChemicalSource: Recombinant GST-tagged protein expressed in E. coli Mr: 71.2 kDa The isolated individual or tandem bromodomains of BRD2 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters.
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SET8 (human recombinant)
Cayman ChemicalSource: Active recombinant N-terminal His-tagged protein amino acids 190-352, expressed in E. coli Mr: 21.1 kDa SET8 selectively mono-methylates histone H4 at lysine 20, an event proven to have an important role in chromatin structure and transcriptional activation. SET8 is also a novel…
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PtdIns-(4,5)-P2 Binding Protein
Cayman ChemicalSource: recombinant N-terminal GST-tagged protein purified from E. coli Mr: ~45.2 kDa (18.9 kDa native; 26.3 kDa GST-tagged) PtdIns-(4,5)-P2 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(4,5)-P2. PtdIns-(4,5)-P2 can be phosphorylated by…
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PAD4 (human recombinant)
Cayman ChemicalSource: Active recombinant N-terminal His-tagged protein expressed in E. coli MW: 75.8 kDa PAD4 is a homodimer that functions as a transcriptional coregulator to catalyze the conversion of specific arginine residues to citrulline in a calcium-dependent manner. PAD4 substrates include histones…
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Protein S from Human Plasma
MP BiomedicalsProtein S is a single chain vitamin K-dependent glycoprotein containing glycine and NaCl which is thought to function in both coagulation and complement cascades. It is produced in the liver and has been identified in plasma at a concentration of approximately 22 µg/mL. Homozygous deficiency…
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JMJD2A-Strep tagged (human recombinant)
Cayman ChemicalSource: Active recombinant N-terminal Strep II-tagged protein expressed in E. coli Mr: 42.7 kDa JMJD2A catalyzes the demethylation of trimethylated forms of histone at lysine residues 9 and 36. JMJD2A is an α-ketoglutarate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC…
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Serum Retinol Binding Protein 4 (human recombinant)
Cayman ChemicalSource: recombinant His-tagged protein purified from E. coli Mr: ~21 kDa
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BRD4 bromodomain 1 (human recombinant; His-tagged)
Cayman ChemicalSource: Recombinant N-terminal His-tagged protein expressed in E. coli Mr: 16.6 kDa The isolated individual or tandem bromodomains of BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters.
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FABP5 (human recombinant)
Cayman ChemicalSource: recombinant N-terminal hexahistidine-tagged protein expressed in E. coli Mr: 18 kDa
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FEN1 (human recombinant)
Cayman ChemicalPeptide sequence: 2-380 Full-length Source: recombinant C-terminal His-tagged protein expressed in E. coli Mr: 43.8 kDa
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Glucose-6-phosphate Isomerase (human recombinant)
Cayman ChemicalRecombinant C-terminal His-tagged protein expressed in E. coli One unit is defined as the amount of enzyme required to reduce 1 µmol of NADP+ to NADPH per minute at 25°C in 50 mM Triethanolamine, pH 7.6, containing 1 mM MgCl2.
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SIRT7 (human recombinant)
Cayman ChemicalSource: Recombinant N-terminal His-tagged enzyme expressed in E. coli Mr: 49.3 kDa SIRT7 activates transcription by RNA polymerase I and deacetylates p53. It prevents progressive deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell…
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CBX1 (human recombinant)
Cayman ChemicalSource: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 48.9 kDa
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JMJD2A (human recombinant)
Cayman ChemicalSource: Active recombinant N-terminal His-tag protein expressed in E. coli Mr: 43 kDa JMJD2A catalyzes the demethylation of trimethylated histone at lysine residues 9 and 36.
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FABP1 (human recombinant)
Cayman ChemicalSource: recombinant N-terminal hexahistidine-tagged protein expressed in E. coli Mr: 18.3 kDa
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pCAF Histone Acetyltransferase
Cayman ChemicalSource: Active recombinant GST-tagged protein expressed in E. coli Mr: ~40 kDa pCAF belongs to the GCN5/pCAF family of nuclear HATs. Cayman’s pCAF preparation contains 165 amino acids from the HAT activity domain of human pCAF fused to GST at the N-terminus. Enzyme activity was…
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Prostaglandin F Synthase (human recombinant)
Cayman ChemicalSource: Active recombinant C-terminal His-tagged protein expressed in E. coli Mr: ~37 kDa Protein concentration: 0.8 mg/ml Human PGFS catalyzes the isomerization of PGH2 to PGF2a (PGH2 9,11-endoperoxide reductase activity), as well as the formation of 11b-PGF2a from PGD2 (PGD2…
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IDH1 (human recombinant)
Cayman ChemicalSource: Recombinant C-terminal His-tagged protein expressed in E. coli MW: 47.9 kDa
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MeCP2 (human recombinant; methyl binding domain aa 77-166)
Cayman ChemicalSource: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 37 kDa MeCP2 specifically binds to methylated promoters on CpG islands and mediates gene silencing by recruiting corepressor complexes. In vitro work suggests high affinity binding of MeCP2 is facilitated by DNA…
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IDH1 R132H mutant (human recombinant)
Cayman ChemicalSource: Active recombinant C-terminal His-tagged protein expressed in E. coli MW: 47.9 kDa
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CBX3 (human recombinant)
Cayman ChemicalSource: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 48.4 kDa
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Thioredoxin 1 (mouse recombinant)
Cayman ChemicalSource: one ampoule contains 100 µg of salt-free recombinant mouse cytosolic thioredoxin Activity: fully active with mammalian thioredoxin reductase
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BARD1 BRCT domains (human recombinant)
Cayman ChemicalSource: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 52.4 kDa
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UHRF1 PHD domain (human recombinant)
Cayman ChemicalSource: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 35.5 kDa
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BRD4 bromodomains 1 and 2 (human recombinant; aa 49-460)
Cayman ChemicalSource: Recombinant GST-tagged protein expressed in E. coli Mr: 73.4 kDa The isolated individual or tandem bromodomains of BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters.
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Core Histones (human)
Cayman ChemicalSource: Highly purified mixture of human core histones (H2A, H2B, H3, and H4) isolated via hydroxyapatite chromatography from HeLa S3 (human cervical adenocarcinoma) nuclear pellet
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JMJD2D-Strep tagged (human recombinant)
Cayman ChemicalSource: Active recombinant N-terminal Strep II-tagged protein expressed in E. coli Mr: 42.6 kDa JMJD2D catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residue 9 (me2/3), leading to transcriptional repression and activation, respectively. JMJD2D is an…
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MBD2 (human recombinant; methyl binding domain aa 150-220)
Cayman ChemicalRecombinant N-terminal GST-tagged protein expressed in E. coli MBD2 specifically binds to methylated promoters on CpG islands. MBD2 binding to 5mC facilitates the recruitment of chromatin remodeling and transcriptional repressor complexes, which results in a repressive chromatin state.