A cyclic LPA analog that contains the 16:1 fatty acid, palmitoleate, at the sn-1 position; at 25 μM inhibits the transcellular migration of MM1 cells across mesothelial cell monolayers without affecting proliferation; significantly inhibits autotaxin (IC50 = 620 nM).

An inhibitor of 15-LO with an IC₅₀ value of 18 µM.

An acylcarnitine formed from carnitine conjugated to arachidonic acid; may be useful as a marker of mitochondrial dysfunction.

Phosphatidylethanolamines are important components of cell membranes and biochemical pathways of fatty acid synthesis. 1-Palmitoyl-2-linoleoyl PE (PLPE) is one of the many phosphatidylethanolamines that may be present in cellular membranes. It has been used in studies involving the biosynthesis of…

C-12 NBD ceramide is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity. It is hydrolyzed efficiently by alkaline ceramidase from P. aeruginosa and by neutral ceramidase from mouse liver. In addition, alkaline and neutral…

A cyclic LPA analog that contains the 18:1 fatty acid, oleate, at the sn-1 position; at 25 μM, inhibits the transcellular migration of MM1 cells across mesothelial cell monolayers without affecting proliferation; at 0.1-1.0 μM, significantly inhibits autotaxin and antagonizes LPA1 (IC50 = 836…

10-Pyrene-PC is a substrate for all PLA2s with the exception of cPLA2 and PAF-AH. Upon phospholipid hydrolysis, 10-pyrenyldecanoic acid is produced from 10-pyrene-PC. The monomeric 10-pyrenyldecanoic acid exhibits fluorescence (excitation 345 nm, emission 395 nm), allowing quantitation of…