Biologically Active Small Molecules, UN1231, 876150-14-0
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Octyl-a-ketoglutarate
Cayman ChemicalA stable, cell-permeable form of α-ketoglutarate which accumulates rapidly and preferentially in cells with a dysfunctional TCA cycle; stimulates PHD activity and increases HIF-1α turnover when used at 1 mM; competitively blocks succinate- or fumarate-mediated inhibition of PHD.
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