Immediate precursor of 4-HNE formed from ω-6 hydroperoxides such as linoleic acid and arachidonic acid.

A COX metabolite of arachidonic acid and precursor for all 2-series ,PGs and TXs; acts as a TP receptor agonist and suicide substrate for TX synthase (Ki = 18 µM).

PGG2 is the first intermediate in the COX pathway which is stable enough to be isolated and characterized. It is the C-15 hydroperoxide of PGH2. Under normal conditions, PGG2 is quickly metabolized by the peroxidase activity intrinsic to both COX-1 and -2 to give PGH2, which serves as the key…

PGH1 is a COX metabolite of DGLA and is the precursor to all 1-series PGs and thromboxanes. PGH1 is a suicide inhibitor of platelet thromboxane synthase with a Ki of 28 µM.