Biologically Active Small Molecules, 500 mg, UN1544
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(+)-Pilocarpine (hydrochloride)
Cayman ChemicalA muscarinic M1 and M2 mACh receptor agonist (pKB = 5 and 3.7, respectively) that is typically used as an animal model for temporal lobe epilepsy.
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Camptothecin
Cayman ChemicalA cytotoxic, quinoline alkaloid that inhibits the DNA enzyme topoisomerase I (Top I) by binding the Top1-DNA cleavage complex and inducing DNA-strand breaks; has strong anti-tumor activity and induces DNA damage at concentrations as low as 51 nM in whole cells and 12 nM in isolated nuclei in in…
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Methotrexate
Cayman ChemicalAn analog of folic acid and aminopterin that is used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions; induces adenosine release, inhibits the metabolism of folic acid, and blocks key enzymes in the synthesis of purines and pyrimidines…
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Colchicine
Cayman ChemicalInhibits microtubule polymerization (IC50 =3.2 μM) by binding to tubulin, which disrupts spindle formation during mitosis; blocks the growth of MCF-7 human breast carcinoma cells (IC50 = 13 nM); inhibits neutrophil motility and activity (5 μmol/kg in a mouse model of…
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Atropine
Cayman ChemicalNon-selective, competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5 (pKBs range from 8.9-9.8); increases firing of the sinoatrial node and conduction through the atrioventricular node of the heart, opposes the actions of the vagus nerve, blocks acetylcholine…
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Monocrotaline
Cayman ChemicalA natural 11-membered macrocyclic pyrrolizidine alkaloid used in an animal model of pulmonary hypertension.