A loop diuretic with good absorption and pharmacodynamic properties; acts as an inhibitor of NKCC1 and the kidney-specific NKCC2 (Ki = 0.5 and 59 μM for human and rabbit NKCC1, respectively).

Bumetanide is a loop diuretic that is clinically used to treat congestive heart failure. Bumetanide exhibits natriuretic activity, inhibiting Na+/K+/2Cl- symporter 1 (NKCC1) and K+/Ca2+ co-transporter 2 (KCC2), decreasing fluid secretion and Na+/K+ transport. Bumetanide also exhibits anxiolytic,…