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Bumetanide has been used to probe the role of prostaglandin E2 in the regulation of chloride secretion across porcine endometrial epithelial cells.

Synonym(s): 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid Formula: C17H20N2O5S Formula weight: 364.40 Purity: 98+% CAS Number: 28395-03-1 Harmonized Tariff Code:  2935.00

A loop diuretic with good absorption and pharmacodynamic properties; acts as an inhibitor of NKCC1 and the kidney-specific NKCC2 (Ki = 0.5 and 59 μM for human and rabbit NKCC1, respectively).

Bumetanide is a loop diuretic that is clinically used to treat congestive heart failure. Bumetanide exhibits natriuretic activity, inhibiting Na+/K+/2Cl- symporter 1 (NKCC1) and K+/Ca2+ co-transporter 2 (KCC2), decreasing fluid secretion and Na+/K+ transport. Bumetanide also exhibits anxiolytic,…