A chromogenic substrate for endoglucanases and cellobiohydrolases.

15(R)-HEDE is isolated by the chromatographic resolution of (±)15-HEDE. There are no reports of biological activity associated with 15(R)-HEDE in the literature.

DAF-2 diacetate is a sensitive fluorescent indicator for the detection and bioimaging of NO. It is a cell-permeable derivative of DAF-2. Upon entry into the cell, DAF-2 diacetate is transformed into the less cell-permeable DAF-2 by cellular esterases thus preventing loss of signal due to diffusion…

8(S)-HETrE is a monohydroxy PUFA produced by rabbit neutrophil lipoxygenase when DGLA is used as a substrate. Although the biological activities of 8(S)-HETrE have not been well characterized, it is expected to behave similarly to 8(S)-HETE.

(±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The individual R and S isomers of racemic HETEs have been separated and identified using chiral phase HPLC. The racemic HETEs have been quantified as an index of lipid…

An aspirin-triggered lipoxin that inhibits LTB4-induced chemotaxis, adherence, and transmigration of the neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.

An isotopically enriched form of a PUFA with carbon-13 occurring at positions 1, 2, 3, 4, and 5; used to study metabolic processes related to arachidonic acid by means of mass spectrometry.

A selective partial agonist of GPR120 that induces ERK activation and intracellular calcium responses in mouse enteroendocrine STC-1 cells that express GPR120 endogenously.

5(S)-HETrE is produced by the action of 5-LO when mead acid is the substrate. There are no literature reports of the biological activity or further metabolic fate of 5(S)-HETrE.

An antifungal antibiotic that selectively inhibits succinate dehydrogenase (complex II; IC50s = 12 and 3.7 nM in nematode and mammalian mitochondria, respectively, versus IC50s > 100 μM for inhibition of complex I and complex III enzymes); has cardioprotective effects against simulated…

(±)11-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelets and canine retina. In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets.…

15-OxoETE is produced by oxidation of the 15-hydroxyl of 15-HETE. Whether this is a major pathway of 15-HETE metabolism is yet to be clearly established.

An antagonist of the inositol 1,4,5-trisphosphate at its carboxy terminus.

An isotopically enriched form of a PUFA standard with carbon-13 occurring at positions 1, 2, 3, 4, and 5; used to study metabolic processes related to arachidonic acid by means of mass spectrometry.

A plant growth regulator with anticancer activity.

A derivative of (±)8(9)-EET which is stable enough to ship and handle routinely.

An internal standard for the quantification of 5-POHSA by GC- or LC-MS.

(±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers (Item Nos. 34560 and 34570). It aggregates neutrophils with an EC₅₀…

An internal standard for the quantification of trans-resveratrol by GC- or LC-MS.

An internal standard for the quantification of (2S)-octyl-α-hydroxyglutarate by GC- or LC-MS.

A group A trichothecene mycotoxin derived by the metabolism of T-2 toxin.

An intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids; also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.

(±)15-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)15-HETE is similar to that of its constituent enantiomers (Item Nos. 34720 and 34710).

(±)16-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.

An autoxidation product of DHA and a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.

15(S)-HpEDE is a monohydroperoxy PUFA produced by the action of 15-LO on eicosadienoic acid. Although the biological activities of 15(S)-HpEDE have not been well characterized, it is expected to behave similarly to 15(S)-HpETE (Catalog No. 44720).

A potent anti-tumor agent used as a selective and irreversible inhibitor of the 20S proteasome; inhibits proteasome activity in cell growth assays (IC50 = 4 nM) and demonstrates potent cytotoxicity against B16-F10, HCT116, and Moser solid tumor cells, as well as P388 and K562 leukemia cells (IC50s…

An inositol-1,4,5-trisphosphate receptor antagonist; completely blocks the increase in intracellular calcium in vascular smooth muscle cells at a concentration of 25 µM.

A natural inhibitor of mitochondrial complex II with antibiotic activities.

Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. 11-dehydro TXB2 is one of the main plasma metabolites of TXB2 and can be used as a marker for in vivo TXA2 synthesis. The mean plasma…

An unusual, yet primary, product of the COX pathway biosynthesized by TX synthase in the human platelet.

A natural analog of 20-hydroxyecdysone and agonist of the ecdysteroid receptor (Kd = 1 nM); used as an agonist in ecdysone-inducible gene expression systems in mammalian cells.