A non-alkaloid toxin lignan that blocks tubulin polymerization, thus, inhibiting mitosis; used as a cathartic, purgative, antiviral agent, vesicant, antihelminthic and the starting material for the semi-synthesis of the anti-cancer drugs etoposide, teniposide, and etopophos.

A pyrrolidine antibiotic produced by S. griseolus that inhibits protein and DNA synthesis and activates stress-activated protein kinase, MAPK, and other signal transduction pathways.

A tumor-inhibiting antibiotic that inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis, N-formylglycineamidine ribotide synthetase and glucosamine-6-phosphate isomerase; also inhibits the hexosamine biosynthetic pathway, which has been shown to protect against…

A non-ionic detergent used to solubilize membrane-bound proteins, to precipitate cholesterol, and to permeabilize cell membranes.