Biologically Active Small Molecules, Cayman Chemical, 100 mg, NEW! Life Science, Bottle, Glass, Clear
Bottle, Glass, Clear NEW! Life Science 100 mg Cayman Chemical Biologically Active Small Molecules
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Pargyline (hydrochloride)
Cayman ChemicalPargyline is an irreversible inhibitor of monoamine oxidase (MAO) that is used clinically to treat moderate hypertension. At 10 mg/kg iv, pargyline induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Daley rats. The…
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Arctigenin
Cayman ChemicalAn extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory, antiproliferative, and antiviral activity.
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Imatinib (mesylate)
Cayman ChemicalA first generation tyrosine kinase inhibitor that is used in the treatment of CML, GIST, and other cancers; selectively targets certain tyrosine kinases, including c-ABL, PDGFR, KIT, and the oncoprotein BCR-ABL.
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1-Palmitoyl-2-oleoyl-3-linoleoyl-rac-glycerol
Cayman ChemicalPOL is a common triglyceride component in seed and vegetable oils including olive, sesame, soybean, canola, corn, hazelnut, and many others. POL is one of the standard triglyceride components used for the USP analysis of sesame oil for pharmaceutical applications.
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Concanavalin A
Cayman ChemicalA plant lectin that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis; widely used in affinity chromatography purifications of various glycoproteins and cellular structures; also used to induce liver injury in…
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Kaempferol
Cayman ChemicalA dietary flavonoid which has diverse physiological activities through both direct and indirect effects; directly binds ERα and ERβ, acting as an inverse agonist or agonist; acts as an antioxidant; suppresses signaling through certain receptor tyrosine kinases, including EGFR and HGF.
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Ibufenac
Cayman ChemicalA NSAID that inhibits COX-1 and -2 activity with IC50 values of 17.4 and 13.1 µM, respectively.
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Glutathione ethyl ester
Cayman ChemicalA cell permeable derivative of GSH that undergoes hydrolysis by intracellular esterases to release GSH; used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals.
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Tenofovir
Cayman ChemicalAn analog of adenosine monophosphate that has antiviral activity; converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and HBV polymerase.
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Linoleic Acid
Cayman ChemicalLinoleic acid is an essential fatty acid and one of the most abundant PUFAs in the western diet. Deficiencies in linoleic acid are linked to defective wound healing, growth retardation, and dermatitis. Linoleic acid is metabolized by 15-LO in both plants and animals to form 9- and 13-HODE.
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4-Pyrimidinecarboxaldehyde, dimethyl acetal
Cayman Chemical4-Pyrimidinecarboxaldehyde, dimethyl acetal is a synthetic intermediate useful for pharmaceutical synthesis.
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Dihomo-y-Linolenic Acid
Cayman ChemicalAn elongation product of γ-linolenic acid (18:3), rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4); metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins; can reduce atopic dermatitis and atherosclerosis when added to the diet of mice.
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Isoprinosine
Cayman ChemicalA complex of acetaminobenzoic acid, dimethylaminoisopropanol, and inosine in a 3:3:1 ratio; has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production; shows antiviral activity.
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Levetiracetam
Cayman ChemicalA second generation antiepileptic compound used to prevent convulsions in a variety of settings; binds the synaptic vesicle protein SV2A (pIC50 = 5.7), presumably altering vesicle exocytosis; alters the metabolism and turnover of GABA.
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a-Linolenic Acid
Cayman ChemicalALA is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.
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Temozolomide
Cayman ChemicalAn imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells; rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier.
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Puromycin (hydrochloride)
Cayman ChemicalAn aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains; used in assays for peptide-bond formation and elongation and also often used as selective agent in cell culture systems.
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Coumarin Boronic Acid pinacolate ester
Cayman ChemicalA fluorescent probe that can react with ONOO-, HOCl, and H2O2 in a similar manner to CBA, yet is formulated for improved solubility.
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Empagliflozin
Cayman ChemicalA selective SGLT2 inhibitor (IC50 = 3.1 nM) that has been shown in clinical trials of patients with type 2 diabetes to lower fasting and postprandial glucose levels by increasing total glucose excretion, improving β-cell function, and shifting substrate utilization from glucose to lipids.
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Nortriptyline (hydrochloride)
Cayman ChemicalA tricyclic antidepressant that blocks norepinephrine and serotonin transporters (KDs = 4.4 and 18 nM, respectively) more potently than the dopamine transporter (KD = 1.1 µM).
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Propidium Iodide
Cayman ChemicalA fluorescent probe commonly used to identify dead cells; excitation at 488-535 nm and emission maximum of 617 nm.
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Necrostatin-1
Cayman ChemicalAn inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 490 nM.
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Pimozide
Cayman ChemicalAn antipsychotic compound that displays high affinity for dopamine receptors (Kis = 2.4, 0.2, and 1.8 nM for D2, D3, and D4, respectively); also has actions as an antagonist, inverse agonist, or channel blocker, with lower affinities, at other receptors and channels.
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ß-cyano-L-Alanine
Cayman ChemicalA reversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase; blocks H2S synthesis in rat liver preparations with an IC50 value of 6.5 µM.
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Ursolic Acid
Cayman ChemicalA natural triterpenoid carboxylic acid that is known to have antioxidative, antimicrobial, anti-inflammatory, and anticancer activities; inhibits Na+/K+-ATPase activity (IC50 = 24.7 μM) and blocks NF-κB activation in various human cancer cells lines (10-100 μM), inhibiting cell…
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Arctiin
Cayman ChemicalThe major active lignin in fruits of the burdock plant A. lappa that demonstrates potent antiviral, anti-inflammatory, and antiproliferative activity.
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Nocodazole
Cayman ChemicalReversibly binds tubulin and alters GTP hydrolysis as well as microtubule dynamics; nanomolar concentrations reduce both microtubule elongation and shortening velocities, resulting in arrest of cycling in a G2/M phase; also used to induce the formation of Golgi ministacks in eukaryotic cells.
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Gly-Phe-ß-naphthylamide
Cayman ChemicalA substrate of cathepsin C that accumulates inside lysosomes causing lysosome degradation; 50 μM can inhibit the cathepsin-dependent activation of caspase-8.
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Dihomo-y-Linolenic Acid ethyl ester
Cayman ChemicalDGLA is a metabolite produced by chain elongation of the essential fatty acid γ-linolenic acid. Ethyl DGLA is an esterified version of the free acid which is less water soluble, but more ammenable for the formulation of DGLA-containing diets and dietary supplements. DGLA has been advanced as…
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Colchicine
Cayman ChemicalInhibits microtubule polymerization (IC50 =3.2 μM) by binding to tubulin, which disrupts spindle formation during mitosis; blocks the growth of MCF-7 human breast carcinoma cells (IC50 = 13 nM); inhibits neutrophil motility and activity (5 μmol/kg in a mouse model of…
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CAY10679
Cayman ChemicalAn anionic oligopeptide-based bola-amphiphile that contains a hexane moiety flanked by a glycylglycine group at each end, which creates distinct hydrophilic and hydrophobic regions.
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3-Pyrimidin-2-yl-Propionic Acid
Cayman Chemical3-Pyrimidin-2-yl-Propionic Acid is a synthetic intermediate useful for pharmaceutical synthesis.