Mode of Action: G-418 inhibits protein elongation by blocking polypeptide synthesis. Eukaryotic cells that are stably transfected with neomycin resistance genes can be selected and maintained using this product. Similar in structure to Gentamicin, Neomycin, and Kanamycin. Store dessicated at…

Product Description Antibiotic. Cytotoxic to prokaryotic and eukaryotic cells by inhibiting the protein synthesis. Apoptosis inducer. Widely employed in the selection of eukaryotic expression vectors, in combination with either aminoglycoside phosphotransferase 3' or APH II. Antiviral. …

G418 is an aminoglycoside related to Gentamicin and is toxic to bacteria, yeast, higher plants, mammalian cells, protozoans and helminths. It blocks polypeptide synthesis in both prokaryotic and eukaryotic cells and is useful for selection of genetically engineered eukarytoic cells in culture.