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Corning® Synthemax® II-SC Substrate

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The Corning Synthemax II-SC Substrate is an easy-to-use, self-coating material for creating a unique synthetic surface that mimics the natural cell environment. This surface supports the adhesion and expansion of stem cells in their undifferentiated state and directed differentiation into specialized cell types. In addition, it offers a synthetic, xeno-free alternative to biological coatings and/or feeder cell layers used in hES and iPS cell culture.

Corning Synthemax II-SC Substrate allows for the scalable multi-passage expansion of pluripotent stem cells indefined media with:

  • Stable doubling time
  • Phenotypicmarker expression (Oct4, SSEA4)
  • Retention of pluripotency
  • Retention of normal karyotype

Current methods to maintain hESCs and iPSCs in an undifferentiated state often employmouse feeder layers or biological substrates. These methods can be problematic as they are difficult to work with, can be inconsistent and introduce the possibility of contamination from the animal source. The development of this new biomimetic surface directly addresses these issues. Corning Synthemax II-SC Substrate is:

  • Easy-to-use
  • Able to coat plastic and glass surfaces
  • Lot-traceable
  • Irradiated
  • Quality tested for lot-to-lot consistency

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Corning® Synthemax® II-SC Substrate, 10 mg Vial
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