Synonyms: 3-(4-pyridinyl)-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazole; 3-(Pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
Molecular Formula: C8H5N5S
Molecular Weight: 203.22
Linear Structural Formula: C8H5N5S
MDL Number: MFCD06590438
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: YU142670 is a selective inhibitor against OCRL1/INPP5F (IC50 = 0.71 muM; substrate = PI(4,5)P2) and OCRL2/INPP5B (IC50 = 0.53 and 1.78 muM; substrate = PI3 and INPP5B/PI(4,5)P2, respectively) by targeting OCRL catalytic domain without affecting INPP5A, INPP5E, PTEN, SHP1, shrimp alkaline phosphatase, sphingomyelinase, or SYNJ1. YU142670 causes an increased PI(4,5)P2/PI4P ratio in human skin fibroblasts (by 50%; 50 muM for 1 h) and induces upregulated actin nucleation and ruffle activity at the plasma membrane without obvious cytotoxicity. Consistent with the negative regulatory role of PtdIns(4,5)P2 against the calcium channel mucolipin-1 (MCOLN1) that controls autophagosome-lysosome fusion, ehnahced autophagosome accumulation is observed in human kidney proximal tubule cells (PTCs) upon YU142670 (25 muM for 3 hr) or OCRL shRNA treatment.