Nystatin is a fungistatic and fungicidal polyene antibiotic. It binds to ergosterol which increases cell membrane permeability in sensitive fungi. Nystatin is mainly clinically active against Candida species. However, it is also reported to be effective against Aspergillus, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatidis, and other yeasts and fungi. Nystatin has also been used to enrich mutants by negative selection in yeasts. The minimum inhibitory concentration (MIC) of Nystatin to Saccharomyces cerevisiae was reported to be 3µg/ml while for clinical isolates of Candida albicans the MIC was reported to be 4-16µg/ml.
Synonyms: Nystatin; Fungicidin; Mycostatin; Fungicidin; Mycostatin
MDL Number: MFCD25541651
Storage: -20C
Biochem Physiol Actions: Mode of Action: Nystatin acts by binding to ergosterols in fungal cell membranes, increasing permeability of the membrane, and creating nystatin/ergosterol based ion channels. It also functions as a lipid raft-inhibiting reagent and as membrane associated cholesterol.Antimicrobial spectrum: Nystatin acts against fungi, yeasts and molds.