Synonyms: (R)-3-(3,4-Dimethoxyphenyl)-1-(3-(4,18-dioxo-22-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-8,11,14-trioxa-5,17-diazadocosanamido)phenyl)propyl (S)-1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate; Bio-SLF; Biotin-conjugated FKBP12WT-directed ligand; Biotin-conjugated SLF ligand; FKBP12WT affinity probe for PROTAC(R) and targeted protein degradation research
Molecular Formula: C52H76N6O13S
Molecular Weight: 1025.26
Linear Structural Formula: C52H76N6O13S
Storage: -20C
Application: Biotin-SLF (bio-SLF) is an FKBP12WT affinity probe useful in chemical biology or targeted protein degradation where FKBP12 is used as a tool protein and its enrichment is required in discovery experiments or assay validation.Related tools:Additional bifunctional tools for FKPB12 variants:
•dTAG-13 (SML2601) for FKBP12F36V; and KB02-SLF (914738), KB03-SLF (914975), and KB04-SLF (913715) for FKBP12WT
•Cereblon (CRBN) affinity probe: Biotin-Thalidomide (913979)
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes: The dTAG system for immediate and target-specific protein degradationTechnology Spotlight: Building PROTAC(R) Degraders for Targeted Protein Degradation