Benzamidine Separopore® 6B is p-aminobenzamidine covalently attached to Separopore® 6B by the epoxy coupling method. p-Aminobenzamidine (PAB), is an inhibitor of trypsin-like serine protease. Trypsin and trypsin-like serine proteases bind to Benzamidine Separopore® 6B and can thus be used for purification and/or removal of these substances.
Benzamidine Separopore® 6B can be used for purifing serine proteases such as trypsin, bovine thrombin, urokinase, human enterokinase, acrosin, native plasminogen, kallikrein, prekallikrein, collagenase and clostripain. For recombinant purification, Benzamidine Separopore® 6B can be used for removal of serine proteases such as thrombin and enterokinase after cleavage of purification tags.