Synonyms: 4-[((4-Carboxy-butyl)-{2-[5-fluoro-2-(4'-trifluoromethyl-biphenyl-4-ylmethoxy)-phenyl]-ethyl}-amino)-methyl]-benzoic acid; 4-[[(4-Carboxybutyl)[2-[5-fluoro-2-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid
Molecular Formula: C35H33F4NO5
Molecular Weight: 623.63
Linear Structural Formula: C35H33F4NO5
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Structurally, BAY 60-2770 comprises fluoro and trifluoromethyl moieties. It stimulates in vitro expressed a2/ß1 isoform of nitric oxide sensitive guanylyl cyclase (NOsGC). BAY 60-2770 is reported to be effective in treating liver fibrosis and in lowering arterial pressures (both pulmonary and systemic) in animal studies. It elicits anti-aggregating and anti-adhesive effects on platelets and may have therapeutic potential to treat atherothrombotic events.