Tumor Necrosis Factor-Alpha (TNF-a) plays a major role in regulating growth, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune diseases. TNF alpha-1a is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells. In addition to inducing…

The histamine receptor H3 is a G_i-coupled GPCR expressed in the thalamus, caudate nucleus, putamen, cerebellum, amygdala, substantia nigra, hippocampus, hypothalamus and cerebral cortex. Activation of H3 receptor in human nasal mucosa inhibits sympathetic vasoconstriction. Expression of…

dGTP (100 mM) ≥99% HPLC

Interleukin-6 Receptor (IL-6R) is a single trans-membrane protein that is the receptor for Interleukin-6 (IL-6). IL-6R forms a hexameric complex upon binding 2 molecules of IL-6 and two molecules of glycoprotein 130 (gp130) which activates intracellular JAK/STAT pathways. Although the normal form…

Donors were untreated and asymptomatic at the time of collection.

The Zika Antibody Control Pack consists of one vial each of IgG, IgM and negative antibody controls.

Molecular Q panels consist of four individual levels, including a negative and are intended to evaluate an assay's clinical range.This dedicated Molecular Q Panel is designed to monitor the performance of molecular assays used in the detection of Norovirus GII. This panel consists of four samples…

Single donor specimens collected from donors prior to and continuing through disease progression.

Interleukin-18 (IL18, also known as interferon-gamma inducing factor or IGIF) is a cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. Its biological activity is pleiotropic and it has been shown to induce interferon-gamma production in KG-1 cells. The…

Single donor specimens collected from donors prior to and continuing through disease progression.

AccuGENE™ Water is considered a “fit for purpose” Type I water and is created for use specifically in molecular biology applications.

The GenBox Mini Blot System is compatible with both the GenBox Mini electrophoresis module as well as the blot modules for tank blotting. The system holds both GenScript's 10*8 and 10*10 precast gels interchangeably.

Evaluate the performance of nucleic acid tests for determination of the presence of Influenza B Virus nucleic acids Formulated with purified, intact organisms Organisms are chemically modified to render them noninfectious Refrigerator stable—store between 2 and 8°C Purified protein matrix treated…

Evaluate the performance of nucleic acid tests for determination of the presence of targeted bacterial nucleic acids Formulated with purified, intact organisms Organisms are chemically modified to render them noninfectious Refrigerator stable—store between 2 and 8°C Purified protein matrix treated…

SUMO tags are emerging as a viable alternative for increasing both the expression and solubility of otherwise hard-to-express proteins. The SUMO tag can be cleanly excised using SUMO protease, which recognizes the conformation of SUMO protein rather than a specific sequence within SUMO. The SUMO…

Evaluate the performance of nucleic acid tests for determination of the presence of Chikungunya Virus nucleic acids Formulated with purified, intact organisms Organisms are chemically modified to render them noninfectious Refrigerator stable—store between 2 and 8°C Purified protein matrix treated…

GenScript Protein A Resin is an affinity chromatography medium designed for easy, one-step purification of classes, subclasses and fragments of immunoglobulins from biological fluids and from cell culture media. Protein A Resin can also be used for immunoprecipitation of proteins,protein complexes…

SYSTAAQ HBV Real Time PCR Kit is an in vitro nucleic acid amplification system used for quantitation of Hepatitis B Virus (HBV) DNA in human serum or plasma. This kit is designed to be used in the treatment of chronic HBV-infected patients having an anti-viral therapy to assess the response with…

Single donor specimens collected from donors prior to and continuing through disease progression.

Leukemia Inhibitory Factor (LIF) is a pleiotropic cytokine belonging to the long four-helix bundle cytokine superfamily. LIF shares tertiary structure with several other cytokines, including Interleukin-6 (IL-6), Oncostatin M, ciliary neurotropic factor, and cardiotrophin-1, and their functions in…

One of Lonza’s highest EEO argaroses, SeaKem® HEEO Agarose is a very high EEO agarose that is useful in applications requiring significant cathodal migration, such as IEP of IgG and IgM. SeaKem® HEEO Agarose can also be used to blend with a lower EEO agarose to achieve a specific EEO…

For The Rapid Qualitative Detection Of Cardiac Markers To Aid In The Diagnosis Of Acute Myocardial Infarction MODERATELY COMPLEX Qualitative Troponin I Enables prompt emergency room decisions Easy to use procedure; Add 3 drops of specimen into device Read results in 15 minutes …

Fibroblast Growth Factor-basic (FGF-basic), also known as FGF-2, is a pleiotropic cytokine and one of the prototypic members of the heparin-binding FGF family. Like other FGF family members, FGF-basic has the ß trefoil structure. In vivo, FGF-basic is produced by a variety of cells, including…

Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine that acts in both pro-inflammatory and anti-inflammatory responses. It is produced mainly by T cells, macrophages, monocytes, endothelial cells and muscle cells. IL-6 binds to IL-6 receptor (IL-6R) to trigger the…

BDCA-2 is a novel type II C-type lectin, which shows 50.7% sequence identity at the amino acid level to its putative murine ortholog, the murine dendritic cell–associated C-type lectin 2. In addition to its antigen capturing function, BDCA-2 can mediate potent inhibition of induction of IFN-a/ß…

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3, and H4. Specifically, the histamine receptor H2 belongs to the rhodopsin-like family of G protein-coupled receptors.…

The thromboxane A2 (TxA2) receptor (TP) is a member of the G protein-coupled receptor (GPCR) superfamily which mediates TxA2-induced platelet aggregation and vasoconstriction. Dysregulation of TxA2 synthesis and function has been implicated in the pathogenesis of a number of disease states…

Interleukin-10 (IL-10), initially known as Cytokine Synthesis Inhibitory Factor (CSIF), belongs to the IL-10 family and shares more than 80% sequence homology with Epstein-Barr Virus protein BCRFI. It is produced by many immune cells, such as T-cells, macrophages, mast cells, and dendritic cells.…

V-domain Ig suppressor of T cell activation (VISTA) is a potent negative regulator of T-cell function that is expressed on hematopoietic cells. VISTA levels are heightened within the tumor microenvironment, in which its blockade can enhance antitumor immune responses in mice. In humans, blockade of…

Following the cloning of the classical opioid receptors (mu, delta and kappa), the opiate receptor like-1 (ORL1) was identified as a G-protein coupled receptor (GPCR) with 65% structure homology to the other members of the opioid family. OPRL1 is a receptor for the 17 aa neuropeptide…

In vitro studies performed on human cell lines demonstrate the immunoregulatory properties of Interleukin-2 (IL-2) including: 1) enhancement of lymphocyte mitogenesis and stimulation of long-term growth of human Interleukin-2 (IL-2) dependent edll lines; 2) enhancement of lymphocyte cytotoxicity;…