Actinonin is an inhibitor of peptide deformylase, matrix metalloproteinase meprin A, and aminopeptidase N (CD13). Actinonin exhibits anticancer, antibiotic, anti-inflammatory, and nephroprotective activities. In Burkitt’s lymphoma cells, actinonin inhibits mitochondrial protein translation, inducing apoptosis. Actinonin exhibits antibacterial efficacy against many gram negative bacteria, including Mycobacterium. Additionally, in animal models of cecal ligation and puncture, actinonin decreases levels of IL-1β, preserving renal morphology and preventing alterations in renal capillary profusion and sepsis.
Grade: ≥98%