Tn5 transposase (Tnp) is a hyperactive retroviral integrase that is used to construct random next-generation sequencing libraries and to study chromatin structure using targeted ATAC-seq. Tn5 transposase can be used to randomly fragment any target DNA and insert unique oligonucleotide adapters in a single in vitro reaction which reduces the time and sample requirements relative to traditional next-gen sequencing library construction.
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