Rifamycin SV is a broad-spectrum semisynthetic antimicrobial agent of the rifamycin group.
Rifamycin SV is used to study potential genes, such as rif15 and rif16, which may be involved in the conversion of rifamycin SV into rifamycin B. It is a potential treatment for traveler’s diarrhea (TD), Clostridium difficile-associated disease (CDAD) and rheumatoid knee synovitis. It is used in electron spin resonance studies.
Rifamycin SV inhibits selective (E. coli, B. subtilis) bacterial DNA-dependent RNA polymerase by binding to the polymerase β-subunit, a mechanism similar to rifabutin. It acts as a selective cytochrome P450 3A4 inducer. It has limited oral absorption that is active against Gram-positive bacteria and is moderately active against Gram-negative organisms.
Key Applications: Treatment of traveler’s diarrhea (TD), Electron spin resonance studies, Study of rif15 and rif16 genes
Application Areas: Used to study potential genes
Product Type: Biochemicals
Biochemical Category: Pharmaceuticals
Chemical Class: Pharmaceuticals
Presentation: Orange Powder
Solubility: ethanol: soluble (50 mg/mL)
Storage & Handling: Store at +4°C. Store Under Nitrogen. Protect from light.