Synonym: Benzylpenicillin sodium salt
CAS Number: 69-57-8
Empirical Formula (Hill Notation): C16H17N2NaO4S
Molecular Weight: 356.37
Beilstein Registry Number: 3834217
EC Number: 200-710-2
MDL Number: MFCD00069666
eCl@ss: 34010400
Biochem/physiol Actions
Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.
Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.
Caution
Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The sodium salt is soluble in H2O at 100 mg/mL.
Application
Penicillin G has been used to study penicillin-binding protein 2[1], and non-toxigenic Corynebacterium diphtheriae isolated from cases of pharyngitis[2].
General Description
Penicillin G is a narrow spectrum natural antibiotic. It is effective against Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus.
Assay: ≥98.0% (N)
Optical Activity: [α]25/D +298±5°, c = 2% in H2O
pH: 5.0-6.5 (3% in H2O)
Solubility: H2O: soluble 0.1 g/mL, clear, colorless
Mode of Action: cell wall synthesis | interferes
Antibiotic Activity Spectrum: Gram-negative bacteria; Gram-positive bacteria
Storage Temp.: 2-8°C