• PRODUCT AVAILABILITY: Did you know you can view a product's availability right on the product page? Simply enter the quantity you want to purchase and the current availability will appear below the item.

  • Product is restricted and can only be purchased by customers with a web profile linked to a Thomas Business Account - Click here to login or create your web profile. If you do not have a Thomas Business Account, please Contact Us and someone will respond with details on how to apply for a business account with us.

Cycloheximide is a glutarimide antibiotic derived from a microbial source. Cycloheximide is an antibiotic which is very active against many molds, yeasts, and phytopathogenic fungi. It exhibits somewhat lower activity against bacteria and certain fungi. Control of various molds and fungi in gelatin-based photographic emulsions, photoengraving glues, and other light-sensitive products is suggested.

Cycloheximide is used in plant research to study disease resistance and as an ethylene stimulant, useful in studies involving fruit and leaf production. It is also used in bacteriological media to isolate or count bacteria in the presence of yeast and molds; Used in protein synthesis in apoptosis; Gene expression; Glycogenolysis, gluconeogenesis and ureogenesis in isolated rat hepatocytes; Studies involving steroidogenesis; Used in plant regulation and as a quality control measure by the food and beverage industry.

Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. Cycloheximide inhibits peptide synthesis in eukaryotic organisms but not in prokaryotes. Protein synthesis is blocked by the interaction of cycloheximide with the translocase enzyme. This interaction prohibits the translocation of messenger RNA on the cytosolic, 80S ribosomes without inhibiting organelle protein synthesis. Cycloheximide is also known to induce FAS/FAS Ligand apoptosis, and triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells in addition to a variety of other cell types. Cycloheximide will also delay or inhibit apoptosis induced by other agents.

Grade: Cell Culture Reagent

Key Applications: Antibiotics, Antifungal

Application Areas: Molecular biology, Cell biology

Product Type: Biochemicals

Melting Point: 103 - 115°C

Presentation: White Powder

Format: Powder

Detection Method: FTIR

Solubility: It is very soluble in chloroform, methanol, and acetone; moderately soluble in isopropanol, n-butanol and amyl acetate; very slightly soluble in carbon tetrachloride and the saturated hydrocarbons. Cycloheximide solubility in water is about 2%. Clear to hazy colorless to light yellow solution at 50mg/mL in ethanol.

Storage & Handling: +4°C

Please Enter Your Order Info

Filter by:

  • Clear Filters
Product Detail
Thomas No.
C822E33
Mfr. No.
0219452701
CAS #
66-81-9
Description
Cycloheximide, 1g
Grade
Cell Culture Reagent
Packaging Size
1 g
Packaging Type
Bottle, Glass, Amber
list price/quantitytotal
$0.00
Thomas No.
C822E34
Mfr. No.
0219452705
CAS #
66-81-9
Description
Cycloheximide, 5g
Grade
Cell Culture Reagent
Packaging Size
5 g
Packaging Type
Bottle, Glass, Amber
list price/quantitytotal
$0.00
Thomas No.
C822E35
Mfr. No.
0219452725
CAS #
66-81-9
Description
Cycloheximide, 25g
Grade
Cell Culture Reagent
Packaging Size
25 g
Packaging Type
Bottle, Glass
list price/quantitytotal
$0.00
$0.00 (0 Items)
Product is restricted and can only be purchased by customers with a web profile linked to a Thomas Business Account - Click here to login or create your web profile. If you do not have a Thomas Business Account, please Contact Us and someone will respond with details on how to apply for a business account with us.

Write A Review