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MP Biomedicals

Chlortetracycline Hydrochloride

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Chlortetracycline hydrochloride has antimicrobial action similar to tetracycline hydrochloride, but it is somewhat less active against many Gram-negative organisms. It was first isolated from the culture of Streptomyces aureofacien.

Cell-permeable fluorescent probe for Ca2+ for measuring calcium flux in endoplasmic reticulum and other intracellular stores in situ.

Chlortetracycline is an antibiotic produced by some strains of Streptomyces aureofaciens. Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit. Antimicrobial spectrum: Gram-positive. Less active against Gram-negative bacterial than tetracycline. Mode of Resistance: Loss of cell wall permeability.

To prepare Stock Solutions: Add the appropriate amount of powder to water while mixing (not the reverse), as adding water to the powders may result in insoluble mixtures that cannot be filtered without losing potency. If desired, the pH may be adjusted, but a basal media with greater than 2 g/L sodium bicarbonate can easily absorb up to 2 % of an acidic antibiotic solution; therefore, an antibiotic solution with an acidic pH would not influence the pH of the media. After ensuring that the resultant solution is transparent, sterile filter and store in small aliquots at appropriate temperature until use. Prior to use of the media, aseptically add the appropriate amount of antibiotic to the basal media in order to obtain the required working concentration. Mix well and sterile filter if asepsis is believed to have been compromised.

Specific Activity: >900 u/mg

Key Applications: Antibacterial, Antibiotics

Application Areas: Molecular biology; Cell biology

Product Type: Biochemicals

Biochemical Category: Antibiotics

Chemical Class: Antibiotics

Melting Point: 243-247°C (dec.)(Lit.)

Presentation: Yellow Powder

Format: Powder

pKa: 3.3, 7.4 and 9.3 at 25°C.(Lit.)

Sulphated Ash: Ash: ≤0.5%

Heavy Metals: <100 ppm

Solubility: The product is tested in 1 M NaOH, giving a clear yellow to brown solution at 50 mg/mL. Its solubility at room temperature in water is reportedly about 8.6 mg/mL, in methanol, 17.4 mg/mL and in ethanol, 1.7 mg/mL. It is soluble in solutions of alkali hydroxides and carbonates. It is practically insoluble in acetone and other organic solvents.(Lit.)

Sterilization of Solutions: Solutions should be filter sterilized. Store in small aliquots at appropriate temperature until use.

Storage & Handling: -20°C, protect from light

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Product Detail
Thomas No.
C823K37
Mfr. No.
0219032705
CAS #
64-72-2
Description
Chlortetracycline Hydrochloride, 5g
Packaging Size
5 g
Packaging Type
Bottle, Glass, Amber
list price/quantitytotal
$0.00
Thomas No.
C823K38
Mfr. No.
0219032725
CAS #
64-72-2
Description
Chlortetracycline Hydrochloride, 25g
Packaging Size
25 g
Packaging Type
Bottle, Glass
list price/quantitytotal
$0.00
Thomas No.
C823K39
Mfr. No.
0219032780
CAS #
64-72-2
Description
Chlortetracycline Hydrochloride, 100g
Packaging Size
100 g
Packaging Type
Bottle, Glass
list price/quantitytotal
$0.00
$0.00 (0 Items)
Product is restricted and can only be purchased by customers with a web profile linked to a Thomas Business Account - Click here to login or create your web profile. If you do not have a Thomas Business Account, please Contact Us and someone will respond with details on how to apply for a business account with us.

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