Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections. Amikacin works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. Amikacin must be given by the intravenous or intramuscular route. There is no oral form available as amikacin is not absorbed orally.
Amikacin is most often used for treating infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter.
Amikacin prevents bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading. It interferes with the translocation of tRNA from the A-site to the P-site.
Potency: ~900 µg/mg
Key Applications: Antibiotic
Application Areas: Molecular Biology
Product Type: Biochemicals
Biochemical Category: Antibiotics
Density: 1.6 g/cm3
Boiling Point: 981.8°C at 760 mmHg
Optical Rotation: +100.5°
Presentation: White Powder
pH: 9.5 - 11.5 (1% aq soln)
Loss on Drying: <9%
Solubility: Sparingly soluble in water.
Storage & Handling: Store at +4°C. Store desssicated.