L-Lysine is an essential proteinogenic α amino acid. It contains an N-butyl amino group in the side chain, and this moiety is protonated at physiological pH. In addition, L-lysine is one of the two amino acids that are degraded to give ketone bodies (a ketogenic amino acid).
L-Lysine is used in a wide range of applications including as a supplement in cell culture media; a substrate of enzymes such as L-lysine oxidase (EC 1.4.3.14); a component of poly-lysine polymers; and a substrate for oxidation and glycation mechanism studies. L-lysine has been used with cultured human osteoblasts to study cell proliferation.
Lysine is degraded in vivo to give acetoacetyl CoA via an initial transamination with alpha-ketoglutarate. L-Lysine is an essential proteinogenic α amino acid used in a wide range of applications including as a supplement in cell culture media; a substrate of enzymes such as L-lysine oxidase (EC 1.4.3.14); a component of poly-lysine polymers; and a substrate for oxidation and glycation mechanism studies.
Product Type: Biochemicals
Biochemical Category: Amino Acids & Peptides
Chemical Class: Amino Acids & Peptides
Melting Point: 215°C (dec.)(Lit.)
Optical Rotation: (c=8, 6 N HCl) +23.5° to +26.5°; +14.6° (65 mg/mL, H2O, 20°C)(Lit.)
Presentation: White Powder
Format: Powder
Isoelectric point (pI): 9.47(Lit.)
pH: 9.9 - 10.3(1% aq soln)
pKa: 2.16 (COOH), 9.06 (α-NH2), 10.54 (N-butyl amino group)(Lit.)
Detection Method: FTIR
Loss on Drying: ≤11.8%
Solubility: Soluble in 0.1N hydrochloride (50 mg/ mL-clear, colorless solution) or water (100 mg/mL - clear, colorless solution).
Storage & Handling: Store at -20°C.