Immunogen: Synthetic peptide from an internal region of human EP3 receptor conjugated to KLH
Host: rabbit
Cross Reactivity: (+) human, bovine, mouse, and rat EP3 receptors; (−) EP1, EP2, and EP4 receptors
Application(s): ICC and WB
As a result of splice variation, the EP3 receptor can be expressed as multiple isoforms that differ in the length and sequence of their C-terminal tails. The signal transduction mechanism varies depending on the isoform being expressed, implicating the importance of the C-terminal region of the receptor for coupling to G-proteins.