Antigen: human 11β-HSD1 amino acids 78-92 (CLELGAASAHYIAGT)
Host: rabbit
Cross-reactivity: (+) human, mouse, and rat 11β-HSD1
Applications: IHC (formalin-fixed paraffin-embedded tissue) and WB
11β-HSD1 catalyzes the conversion of inactive cortisone to active cortisol in adipose tissue. Over-expression of 11β-HSD1 results in visceral obesity and metabolic syndrome including insulin-resistant diabetes, hyperlipidemia, and hyperphagia.