(±)12-HpETE is one of the six monohydroperoxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid (Item No. 90010) and consists of an equal mixture of the R and S isomers. Reduction of the hydroperoxide yields the more stable hydroxyl fatty acid (±)12-HETE (Item…

Key urinary metabolite of PGD2; represents approximately 1% and 4% of the infused radiolabeled dose in monkeys and humans, respectively.

The diol resulting from the sEH opening of (±)11(12)-EET; contracts artery rings with approximately 70% of the magnitude of (±)11(12)-EET.

(±)11-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelets and canine retina. In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets.…

(±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers (Item Nos. 34560 and 34570). It aggregates neutrophils with an EC₅₀…

A purified enantiomer of (±)9-HETE resulting from non-enzymatic oxidation of arachidonic acid.

A minor CYP450 metabolite of arachidonic acid that stimulates vasodilation of rabbit kidney.

Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes. iPF2α-VI is one of dozens of possible stereo- and…

8(S)-HETrE is a monohydroxy PUFA produced by rabbit neutrophil lipoxygenase when DGLA is used as a substrate. Although the biological activities of 8(S)-HETrE have not been well characterized, it is expected to behave similarly to 8(S)-HETE.

A major CYP450 metabolite of arachidonic acid that is released from the kidney in response to angiotensin II; a potent vasodilator of renal preglomerular vessels.

A biologically active peroxidation product of linoleic acid; activates an ARE in neuronal cells and induces the expression of ARE-regulated cytoprotective genes; also stimulates the synthesis of aldosterone and corticosterone in adrenal cells when supplied at 1-5 μM.

(±)16-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.

An autoxidation product of DHA and a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.

15(S)-HpEDE is a monohydroperoxy PUFA produced by the action of 15-LO on eicosadienoic acid. Although the biological activities of 15(S)-HpEDE have not been well characterized, it is expected to behave similarly to 15(S)-HpETE (Catalog No. 44720).

A racemic version of an epoxide produced by CYP450 metabolism of AEA.

An internal standard for the quantification of LTD4 by GC- or LC-MS.

(±)15-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 15(S)-HEPE and 15(R)-HEPE. Specific biological activity attributed to (±)15-HEPE has not been documented.

Racemic version of a CYP450 and epoxide hydrolase metabolite of EPA.

An unusual, yet primary, product of the COX pathway biosynthesized by TX synthase in the human platelet.

An aspirin-triggered epimer of RvD1; reduces human leukocyte transendothelial migration (EC50 = ~30 nM), and limits leukocyte infiltration in a mouse model of peritonitis.

A major arachidonic acid metabolite from the 15-LO pathway.

A metabolite of LTB4 in human neutrophils; inhibits LTB4-induced degranulation of human neutrophilis (Ki = 13.3 nM).

N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans. N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstricting agent. In healthy human subjects urinary excretion of N-acetyl LTE4 is…

15(S)-HEDE is produced from 11Z,14Z-eicosadienoic acid by 15-LO. 15(S)-HEDE is an inhibitor of RBL-1 cell 5-LO with an IC₅₀ value of 26 µM.

The racemic version of a CYP450 metabolite of arachidonic acid that potently inhibits proximal tubule ATPase activity.

A theoretical 5-LO metabolite of AEA; acts as a potent antagonist of the human BLT1 receptor (Ki = 1.22 nM).

Racemic verion of the epoxide biosynthesized in rat and rabbit liver microsomes by CYP450.

An isomer of LTB4 which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA4 hydrolase; has significantly reduced activity compared to LTB4.

A minorCYP450 metabolite of arachidonic acid that potently inhibits proximal tubule ATPase activity.

15-OxoEDE is produced by the oxidation of 15-HEDE. 15-oxoEDE inhibits 5-LO from RBL-1 cells with an IC₅₀ of 55 µM, which is about 2-fold lower than 15(S)-HEDE. A related oxo-eicosanoid, 5-oxoETE, is biosynthesized from 5(S)-HETE by a specific dehydrogenase and has potent…

Racemic version of a CYP450 and epoxide hydrolase metabolite of arachidonic acid.

(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE…