Keystone essential fatty acid that is converted by COX, LO, and epoxygenase enzymes into more than 150 potent metabolites in species ranging from fungi to plants to mammals.

Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Arachidonic acid oxidizes spontaneously on exposure to room air, yielding a complex mixture of fatty acid peroxides. Peroxide-free arachidonic acid is obtained after removal of the…