15(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 15(S)-HETE by GC- or LC-MS.

An internal standard for the quantification of 8,12-iso-iPF2α-VI by GC- or LC-MS.

An internal standard for the quantification of LTB4 by GC- or LC-MS.

An internal standard for the quantification of 2-AG by GC- or LC-MS.

An internal standard for the quantification of PGE2-1-glyceryl ester by GC- or LC-MS.

A thioester substrate analog of 2-AG that can be utilized for the measurement of MAGL activity; hydrolysis of the thioester bond by MAGL generates a free thiol that reacts rapidly with the chromogenic reagent DTNB resulting in a yellow product with an absorbance maximum at 412 nm.

A form of DAG where both acyl groups consist of the 18:1 oleoyl chain; binds the C1 domain and activates conventional PKC forms and serves as a substrate for diacylglycero kinases and multisubstrate lipid kinase.

5(S)-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of 5(S)-HETE. The ability of (±)5-HETE lactone to inhibit RBL-1 cell 5-LO (IC₅₀ = 27 µM) may be entirely due to the 5(S) isomer, but the enantiomers…

An internal standard for the quantification of PGF2α-1-glyceryl ester by GC- or LC-MS.

An internal standard for the quantification of SAG by GC- or LC-MS.

A cell permeable analog of the PKC-activating second messenger DAG.

5(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 5(S)-HETE by GC- or LC-mass spectrometry (MS).

An analog of DAG, which inhibits the activation of PKC by DAG.

A congener of 2-AG in which a linoleoyl group replaces the arachidonoyl group that potentiates the activity of other endocannabinoids, including 2-AG; this “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to rapidly reduce…

A cell-permeable AM ester of the fluorescent calcium indicator fluo-3.

A novel CYP450 metabolite of 2-AG in the kidney; acts as a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells at concentrations as low as 100 nM and doubling cell proliferation rates at 1 µM.

An internal standard for the quantification of 13-OxoODE by GC- or LC-MS.

A HSL member that is produced by the F2/5 strain of A. vitis, the bacterium responsible for grape crown gall and its resulting loss of agricultural productivity.

OAG is a cell-permeable analog of the PKC-activating second messenger DAG. It activates PKC in platelets, resulting in the phosphorylation of a 40 kDa protein. OAG is metabolized to its corresponding phosphatidic acid (1-oleoyl-2-acetyl-3-phosphoglycerol), most likely through the action of a…

A fatty acid glycerol that has been isolated from S. chinensis roots, inhibits PAF-AH with an IC50 value of 45 µM.

An endogenous CB receptor ligand that is 10-100 times less potent than 2-AG in ligand binding affinity and agonist activity at the CB1 receptor; 2-AG undergoes rapid isomerization to 1-AG, which makes it a frequent contaminant in synthetic 2-AG preparations, markedly reducing their cannabinergic potency.

An analog of the PKC-activating second messengers collectively called DAG; equipotent to 1,2-dioctanoyl-sn-glycerol in induction of the acrosome reaction in human sperm.

12(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14 and 15 positions. It is intended for use as an internal standard for the quantification of 12(S)-HETE by GC- or LC-mass spectrometry (MS).

A potent and selective inhibitor of HDAC6 (IC₅₀ = 36 nM) that poorly blocks other HDAC enzymes; cell permeable, inhibiting the acetylation of tubulin in cells with an IC₅₀ value of 210 nM.

An internal standard for the quantification of ent-8-iso-15(S)-PGF2α by GC- or LC-MS.

An endogenous agonist of the CB1 and CB2 receptors; it is the most abundant molecular species of monoacylglycerol found in rat brain.

An internal standard for the quantification of PGE2-1-glyceryl ester by GC- or LC-MS.

An internal standard for the quantification of 9-OxoODE by GC- or LC-MS.

A non-enzymatic, free radical peroxidation product of arachidonic acid; acts as a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 15 and 24 nM, respectively; approximately ten-fold more potent than 8-iso-PGF2α in a whole blood platelet aggregation…

An internal standard for the quantification of 2-AG by GC- or LC-MS.

12-epi Leukotriene B4-d4 (12-epi LTB4-d4) contains four deuterium atoms at the 6, 7, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 12-epi LTB4 by GC- or LC-mass spectrometry.

13(S)-HODE-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of 13(S)-HODE by GC- or LC-MS.