Inhibits microtubule polymerization (IC₅₀ =3.2 μM) by binding to tubulin, which disrupts spindle formation during mitosis; blocks the growth of MCF-7 human breast carcinoma cells (IC₅₀ = 13 nM); inhibits neutrophil motility and activity (5 μmol/kg in a mouse model of…

A natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM); also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM).

Synonym(s): (S)-(+)-Camptothecin Formula: C20H16N2O4 Formula weight: 348.35 CAS Number: 7689-03-4 UN Number: UN1544 Hazard Class: 6.1 Packing Group: III Harmonized Tariff Code:  2939.99 Hazard Statements: H301 Toxic if swallowed. Precautionary Statements: …

An analog of folic acid and aminopterin that is used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions; induces adenosine release, inhibits the metabolism of folic acid, and blocks key enzymes in the synthesis of purines and pyrimidines…

A cytotoxic, quinoline alkaloid that inhibits the DNA enzyme topoisomerase I (Top I) by binding the Top1-DNA cleavage complex and inducing DNA-strand breaks; has strong anti-tumor activity and induces DNA damage at concentrations as low as 51 nM in whole cells and 12 nM in isolated nuclei in in…

Synonym(s): Acetylbenzoylaconine Formula: C34H47NO11 Formula weight: 645.75 Purity: 98% CAS Number: 302-27-2 UN Number: UN1544 Hazard Class: 6.1 Packing Group: I Harmonized Tariff Code:  2939.99 Hazard Statements: H300-H330 Fatal if swallowed. Fatal if inhaled. …