A cell-permeable, competitive, and irreversible inhibitor of all caspases, inhibiting cleavage of PARP and preventing apoptosis when used at 10-50 µM; blocks caspase-mediated apoptosis in vivo; effectively prevents caspase action in inflammasomes.

The novel Z-VAD(OMe)-FMK inhibitor synthesized using proprietary technology is cell permeable and irreversibly binds to activated Caspases to block apoptosis. Apoptosis is a physiological form of cell death, which plays an important role in embryogenesis, cellular homoestasis, tissue atrophy, and…