A phorbol ester that is commonly used to activate certain types of protein PKC and, indirectly, certain MAP kinase pathways; prolonged treatment with PMA produces various effects, ranging from tumorigenesis to hematopoietic differentiation.

PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

Synonym(s): PMA, TPA Formula: C36H56O8 Formula weight: 616.83 Purity: 99+% CAS Number: 16561-29-8 Harmonized Tariff Code:  2915.90 Hazard Statements: H315 Causes skin irritation. Precautionary Statements: P280-P264-P362-P321-P332+P313-P302+P352 Wear protective…

Product Description Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by…