Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages. This receptor is also expressed in brain, liver, lung, and kidney tissues. Chemerin (TIG2) has been identified as the natural ligand for this receptor. Resolvin…

Adenosine Receptor A_2A is a multi-pass membrane protein that is normally localized to the plasma membrane. This receptor is part of the G-protein coupled receptor family that binds adenosine and keeps it in equilibrium inside and outside the cell. Along with establishing this…

The PLA₂ superfamily consists of multiple enzymes that catalyze the hydrolysis of fatty acids from the sn-2 position in phospholipids. AdPLA₂ is the first member of Group XVI phospholipases (PLA). This pH- and calcium-dependent phospholipase is highly expressed in adipose…

GPR17 is a G protein-coupled receptor that has been identified as a dualistic receptor recognizing signals from two unrelated chemical families: nucleotides and cysteinyl leukotrienes (CysLTs). The deorphanization of GPR17 supports the suggested crosstalk between nucleotides and CysLTs during…