A cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit polymerization at concentrations as low as 0.2 µM.

A cell-permeable mycotoxin which binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments; blocks diverse cellular functions, including cell division, migration, phagocytosis, exocytosis, chemotaxis, and glucose transport.

Synonym(s): Phomin Formula: C29H37NO5 Formula weight: 479.61 CAS Number: 14930-96-2 UN Number: UN1544 Hazard Class: 6.1 Packing Group: II Harmonized Tariff Code:  2934.99 Hazard Statements: H300-H310-H330-H361 Fatal if swallowed. Fatal in contact with skin. Fatal if…

Inhibits actin polymerization; uniquely inhibits HIV-1 protease (IC50 = 3 μM); rapidly and reversibly inhibits glucose transport by competitively binding glucose transporters (Ki = 4.0 μM); induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc.

A full GABAA agonist and partial GABAC agonist; binds GABAA on both high- and low-affinity sites (Kd = 10 and 270 nM, respectively), stimulating chloride efflux with an EC50 of 200 nM; activates GABAC receptors with an EC50 of 1.3 μM; impairs memory formation and retrieval; attenuates airway constriction.

A natural sesquiterpene alkaloid that inhibits AChE in rat cortex in vitro (IC₅₀ = 82 nM) and displays oral AChE inhibitory activity in animals.