1.0 mg, UN1170
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Arachidonoyl Ethanolamide
Cayman ChemicalAn endogenous CB neurotransmitter that binds to both CB1 and CB2 receptors.
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(S)-(+)-Docosahexaenyl-2'-Hydroxy-1'-Propylamide
Cayman ChemicalA homolog of DHEA, characterized by the addition of an (S)-β-methyl group at the terminal ethanolamine carbon.
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Oleyloxyethyl Phosphorylcholine
Cayman ChemicalOleyloxyethyl phosphorylcholine is an inhibitor of PLA2 with an IC50 value of 6.2 µM for porcine pancreatic PLA2.
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PAF C-18:1
Cayman ChemicalA naturally occurring phospholipid produced by cells upon inflammatory stimulation; less potent than PAF C-16 and PAF C-18 in the induction of neutrophil chemotaxis, but is equipotent to PAF C-16 and PAF C-18 in promoting eosinophil migration.
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(+)-15-epi Cloprostenol
Cayman ChemicalCloprostenol is a synthetic PGF2α analog and a potent FP receptor agonist. (+)-15-epi Cloprostenol is the 15(S), or 15β-hydroxy enantiomer of (+)-cloprostenol. This epimer is less active by several orders of magnitude as an FP receptor ligand when compared to 15(R)-cloprostenol. However,…
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15(S)-Fluprostenol
Cayman Chemical(+)-15(R)-Fluprostenol isopropyl ester is a prodrug (Travoprost) which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid. The free acid, (+)-15(R)-fluprostenol, is a potent FP receptor agonist. The 15(R)-epimers of most PGs are about 100 times less…
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Ionomycin
Cayman ChemicalA selective calcium ionophore that mobilizes intracellular calcium stores. It is used as a research tool to raise the intracellular level of calcium, to study calcium transport across biological membranes, and to stimulate the intracellular production of cytokines.
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N-Arachidonyl Maleimide
Cayman ChemicalNAM is a potent, irreversible inhibitor of MAGL or MAGL-like activity in rat cerebellar membranes, exhibiting an IC50 value of 140 nM. Inhibition of MAGL by the sulfhydryl-reactive maleimide group of NAM suggests a critical cysteine residue is present in the substrate-binding site of the enzyme.
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ß-Tocotrienol
Cayman ChemicalAn isomer of Vitamin E that has less potent antioxidant properties than α-tocotrienol.
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Dihomo-y-Linolenic Acid ethyl ester
Cayman ChemicalDGLA is a metabolite produced by chain elongation of the essential fatty acid γ-linolenic acid. Ethyl DGLA is an esterified version of the free acid which is less water soluble, but more ammenable for the formulation of DGLA-containing diets and dietary supplements. DGLA has been advanced as…
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Calcium Ionophore I
Cayman ChemicalA Ca2+-selective ionophore for biological membranes that can be used in microelectrodes for the determination of resting Ca2+-activities and of slowly changing Ca2+ levels.
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Eicosapentaenoyl Ethanolamide
Cayman ChemicalAn N-acylethanolamide that inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes; also has anti-inflammatory properties, suppressing the expression of IL-6 and MCP-1 in 3T3-L1 adipocytes in response to lipopolysaccharide.
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N-Arachidonoyl-L-Serine
Cayman ChemicalAn endocannabinoid analog that does not bind to CB1, CB2, or TRPV1; at 5 mg/kg antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-CBD) in an anesthetized rat blood pressure model; relaxes isolated rat mesenteric arteries and abdominal aorta, and increases the…
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Dihomo-y-Linolenic Acid
Cayman ChemicalAn elongation product of γ-linolenic acid (18:3), rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4); metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins; can reduce atopic dermatitis and atherosclerosis when added to the diet of mice.
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(R)-(-)-Docosahexaenyl-2'-Hydroxy-1'-Propylamide
Cayman ChemicalA homolog of DHEA, characterized by the addition of an (R)-β-methyl group at the terminal ethanolamine carbon.
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(+)-5-trans Cloprostenol
Cayman ChemicalA minor impurity produced in the synthesis of (+)-cloprostenol; 20-fold less active than (+)-cloprostenol in terminating pregnancy in the hamster.
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L-902,688
Cayman ChemicalA potent and selective agonist of the human PGE2 receptor, EP4 with a Ki value of 0.38 nM and an EC50 value of 0.6 nM; induces thermal hyperalgesia when injected into guinea pig forepaw and increases vasodilation of human pulmonary vein.
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4-hydroxy Nonenal
Cayman ChemicalA lipid peroxidation product derived from oxidized ω-6 PUFAs such as linoleic acid and arachidonic acid which is widely used as a marker of lipid peroxidation.
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Docosapentaenoic Acid methyl ester
Cayman ChemicalA more lipid-soluble form of DPA amenable to analysis using gas chromatography; may serve as a prodrug, since it should facilitate uptake of DPA and then be hydrolyzed by esterases to generate the free acid after uptake into cells.
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DAN-1 EE (hydrochloride)
Cayman ChemicalDAN-1 EE is a fluorescent indicator for the bioimaging of NO. DAN-1 EE is a cell permeable derivative of DAN, a molecule which has been used extensively in the quantitation of nitrate and nitrite using fluorescence spectroscopy. Upon entry into the cell, DAN-1 EE is transformed into the less cell…
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Oleoyl Serotonin
Cayman ChemicalA hybrid molecule patterned after N-arachidonoyl serotonin; inhibits capsaicin-induced TRPV1 channel activation (IC50 = 2.57 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM).
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AM404
Cayman ChemicalAn analog of AEA that potentiates the activity of endogenous AEA by blocking its re-uptake into presynaptic neurons; selectively inhibits the carrier-mediated transport of AEA without affecting anandamide hydrolysis; inhibits the transport of AEA with an IC50 value of 1 µM in rat…
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a-Tocotrienol
Cayman ChemicalThe four tocopherols (α, β, .delta., and γ) and four tocotrienols (α, β, .delta., and γ) are forms of vitamin E, which is known for its antioxidant activity. Tocotrienols are found at high concentrations in palm oil and rice bran. Recent studies show tocotrienols…
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Pinolenic Acid methyl ester
Cayman ChemicalPinolenic acid methyl ester is a neutral, more lipophilic form of the free acid.
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(S)-(-)-Eicosapentaenyl-1'-Hydroxy-2'-Propylamide
Cayman ChemicalA homolog of EPEA, characterized by the addition of an (S)-α-methyl group at the methylene carbon adjacent to the amide nitrogen.
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KDdiA-PC
Cayman ChemicalOxidized LDL (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the…
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Heneicosapentaenoic Acid methyl ester
Cayman ChemicalA prodrug formulation of HPA which may be useful in various biochemical studies and as a reference standard in analytical work.
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AV-Ceramide
Cayman ChemicalA fluorescently-tagged probe consisting of C-10 ceramide with an AV group attached to the end of the acyl chain.
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(±)-Enterolactone
Cayman ChemicalDiets high in fiber contain plant lignan species that may be directly responsible for some observed health benefits of these diets. Enterolactone is an enterobacterial breakdown product of plant lignans that is absorbed and can be measured in human serum. Enterolactone and other ligans and…
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A lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α.
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Arachidonoyl-2'-Fluoroethylamide
Cayman ChemicalAn analog of AEA in which the alcohol of the ethanolamide group has been replaced with a fluorine atom, which increases the binding affinity and selectivity for the CB1 receptor; in vivo activity is enhanced much less than the binding affinity, because it is rapidly hydrolyzed by FAAH.
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w-3 Arachidonic Acid
Cayman Chemicalω-3 Arachidonic acid is a rare PUFA found in trace amounts in dietary sources. ω-3 Fatty acids are now known to be essential for infant growth and development and protect against heart disease, thrombosis, hypertension, and inflammatory and autoimmune disorders. In human platelet…