A non-selective NSAID exhibiting IC50 values of 0.5 and 2.33 µM for human recombinant COX-1 and COX-2, respectively.

(S)-Naproxen is a non-selective COX inhibitor. The IC₅₀ values for human recombinant COX-1 and -2 are 0.6-4.8 µM and 2.0-28.4 µM, respectively.

An NSAID thought to exert its actions by a prostanoid-independent mechanism; inhibits fMLP- and A23187-induced Ca2+ influx in human neutrophils with an IC₅₀ value of approximately 20 µM.

Ketorolac is a non-selective COX inhibitor. The IC₅₀ values for human recombinant COX-1 and -2 are 31.5 µM and 60.5 µM, respectively.

Nimesulide is a selective inhibitor of COX-2. The IC₅₀ values are 70 and 1.27 µM for human recombinant COX-1 and -2 (at 20 µM arachidonic acid), respectively, and 22 and 0.03 µM for ovine COX-1 and -2 (at 100 µM arachidonic acid), respectively.

A non-selective COX inhibitor; inhibits human recombinant COX-1 and -2 with IC₅₀ values of 0.04 and 0.51 µM, respectively.