Cayman Chemical, 50 g
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Propylthiouracil
Cayman ChemicalA derivative of thiouracil which has long been used to correct hyperthyroidism; also used as a genetic marker for taste, since only some people detect it as a bitter taste.
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Aminoguanidine (hydrochloride)
Cayman ChemicalAminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS. The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 µM, respectively. Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.
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L-DOPA
Cayman ChemicalA metabolic precursor of dopamine that crosses the blood brain barrier; used to treat Parkinson’s disease and stroke damage.
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ß-Glycerophosphate (sodium salt hydrate)
Cayman ChemicalA protein phosphatase inhibitor that acts as a phosphate group donor in matrix mineralization studies; 10 mM accelerates calcification of cultured vascular smooth muscle cells through an alkaline phosphatase-related mechanism.
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Coomassie Blue R-250
Cayman ChemicalA dye that is commonly used in laboratories to stain or quantify proteins; typically gives blue bands on a clear background with a sensitivity of 50-100 ng/band; displays metachromasia by appearing pink-red, rather than blue, when binding certain proteins, such as collagen and histone H1.
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Promethazine (hydrochloride)
Cayman ChemicalA first generation histamine H1 receptor antagonist (Ki = 2.6 nM) that also inhibits muscarinic acetylcholine receptors (Ki = 22 nM); penetrates the CNS, depressing central H1 receptor activity, which may relate to its sedative properties.
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Bromophenol Blue
Cayman ChemicalCommonly used as a pH indicator, a color marker in agarose or polyacrylamide gel electrophoresis, and a dye to detect proteins and nucleic acids (absorbance at 610 nm), particularly when staining living tissues.
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4-Aminopyridine
Cayman ChemicalA non-selective blocker of voltage-dependent K+-channels (Kv channels) that has greatest potency at Kv1 and Kv3 family members (IC50s = 290, 590, 195, 13, 29, and 100 µM for subunits 1.1, 1.2, 1.3, 1.4, 3.1, and 3.2, respectively); also blocks Kv2 and Kv4 subunits at millimolar concentrations.
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Trimethoprim
Cayman ChemicalA synthetic antibiotic that inhibits dihydrofolate reductase (DHFR), with prominent selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively); commonly used in combination with sulfamethoxazole to minimize acquired resistance.
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ß-Carotene
Cayman ChemicalA red/orange-colored fat-soluble terpenoid with antioxidant properties; can be cleaved to produce vitamin A and retinoic acid.
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L-Ascorbic Acid 2-phosphate (magnesium salt)
Cayman ChemicalA long-acting ascorbic acid derivative that stimulates collagen expression and formation and is used in human cell culture; included in media to enhance the survival of human embryonic stem cells or drive osteogenic differentiation in human adipose stem cells and in human mesenchymal stromal/stem cells.
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Retinyl Acetate
Cayman ChemicalA natural form of vitamin A that is thermally more stable than retinol; can reduce cell proliferation and promote differentiation.
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Adenosine 5'-triphosphate (sodium salt)
Cayman ChemicalA central component of energy storage and metabolism in vivo, providing the metabolic energy to drive metabolic pumps and serving as a coenzyme in a wide array of enzymatic reactions; acts a substrate for kinases involved in cell signaling and of adenylate cyclases that produce the second messenger cAMP.
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Luminol
Cayman ChemicalA cyclic diacyl hydrazide that exhibits chemiluminescence upon oxidation; HRP combined with H2O2 causes luminescent peroxidation of luminol; can also be oxidized, and chemiluminesce, by compounds containing iron, copper, gold, and cyanide.
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Oxytetracycline
Cayman ChemicalA broad-spectrum tetracycline antibiotic that inhibits protein synthesis in both Gram-positive and Gram-negative bacteria.
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Brilliant Blue G
Cayman ChemicalA dye which stains proteins in gels with ease and sensitivity; used in the Bradford to quantify the amount of protein in a solution; selectively inhibits P2X7 (IC50s = 10.1 nM and 265 nM for rat and human P2X7, respectively) and reduces neurological injury secondary to traumatic brain…
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Probucol
Cayman ChemicalA potent antioxidant that inhibits the oxidation of cholesterol in LDL and HDL by impairing the translocation of ABCA1 from intracellular compartments to the plasma membrane.
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Ampicillin (sodium salt)
Cayman ChemicalAn antibacterial antibiotic that acts by interfering directly with the biosynthesis of peptidoglycan, which constitutes the major component of the bacterial cell wall, leading to structural instability and death of bacteria; used as a selective antibiotic for resistant bacteria.
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Tetrazolium (chloride)
Cayman ChemicalA redox indicator used to detect cellular respiration; primarily reduced by Complex I in mitochondria and, under anaerobic conditions, is completely reduced to an insoluble red 1,3,5-triphenylformazan.
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Palmitic Acid
Cayman ChemicalA common 16-carbon saturated fatty acid that represents 10-20% of the normal human dietary fat intake.
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2-Thenoyltrifluoroacetone
Cayman ChemicalAn inhibitor of respiration in animals and bacteria; binds at the quinone reduction site of succinate:ubiquinone oxidoreductase (SQR; Complex II) in animals, preventing ubiquinone from binding; inhibits NADH fumarate reductase in bacteria; inhibits photosystem II in plants.
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Quercetin
Cayman ChemicalA flavonoid compound found in the bark and rinds of many plants and fruits.
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Vitamin K3
Cayman ChemicalA precursor to Vitamin K2 that is capable of both redox cycling and arylating nucleophilic substrates by Michael addition; used as an antihemorrhagic agent and to inhibit the proliferation of various cancer cells.
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5-Fluorouracil
Cayman ChemicalA pyrimadine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis; widely used to treat many gastrointestinal tract adenocarcinomas.
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Glycyrrhizic Acid (ammonium salt)
Cayman ChemicalA natural agonist of the human sweet taste receptor and used as a flavorant; has diverse cellular effects at low doses, including antioxidant, anti-inflammatory, antimicrobial, and antiviral actions.
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Syringic Acid
Cayman ChemicalA naturally occurring O-methylated phenolic acid that can be enzymatically degraded by some bacteria as a source of methane or methanol; inhibits aldose reductase (IC50 = 213 µg/ml), proteasome activity, and cancer cell proliferation.
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Aspirin-50 g
Cayman ChemicalA non-selective, irreversible COX inhibitor with IC50 values of 0.75 and 1.25 mM for ovine COX-1 and COX-2, respectively.
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Sodium Butyrate
Cayman ChemicalA short chain fatty acid that inhibits HDACs, induces growth arrest, differentiation and apoptosis in cancer cells, and suppresses inflammation by reducing the expression of pro-inflammatory cytokines.
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Protocatechuic Acid
Cayman ChemicalA dihydroxybenzoic acid phenolic compound that demonstrates free radical scavenging capability (IC50 = 16.3 μM) in a DPPH radical scavenging activity assay; possesses anti-inflammatory, antihyperglycemic, neuroprotective, and anticancer activities.
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Chlorzoxazone
Cayman ChemicalA benzoxazolone derivative that causes skeletal muscle relaxation and blocks spasticity in clinical studies; enhances KCa2.2 and KCa3.1 channels (EC50s = 87 and 98 µM, respectively); urinary excretion of its 6-hydroxy metabolite is often used as a probe of CYP2E1 activity in…
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Tyramine
Cayman ChemicalA trace amine that activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 µM for rat, mouse, and human-rat chimera receptors, respectively); inhibits the release of norepinephrine and dopamine (IC50s = 40.6 and 119 nM, respectively).