Cayman Chemical, 25 µg
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5-iPF2a-VI
Cayman ChemicalIsoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes. iPF2α-VI is one of dozens of possible stereo- and…
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Leukotriene A3 methyl ester
Cayman ChemicalBiosynthesis of LTA3 occurs from 5,8,11-eicosatrienoic acid via the 5-LO pathway{689} and it is the putative intermediate in the biosynthesis of 3-series leukotrienes. LTA3 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.
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tetranor-PGAM
Cayman ChemicalA dehydration product of tetranor-PGEM that can be measured as a surrogate for tetranor-PGEM levels in urine.
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9(S)-HETE
Cayman ChemicalA purified enantiomer of (±)9-HETE resulting from non-enzymatic oxidation of arachidonic acid.
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Resolvin D3
Cayman ChemicalA DHA-derived product first identified in mouse inflammatory exudates; reduces neutrophil infiltration in vivo in both mouse peritonitis and dermal inflammation; enhances macrophage phagocytosis and efferocytosis.
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GDF11 (human recombinant)
Cayman ChemicalSource: Recombinant protein expressed in E. coli MW: 12.5 kDa
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(±)9-HETE
Cayman Chemical(±)9-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The individual R and S isomers of racemic HETEs have been separated and identified using chiral phase HPLC. The racemic HETEs have been quantified as an index of lipid…
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Prostaglandin F2a-d4
Cayman ChemicalAn internal standard for the quantification of PGF2α by GC- or LC-MS.
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19(R)-HETE
Cayman ChemicalA major CYP450 metabolite of arachidonic acid that is released from the kidney in response to angiotensin II; a potent vasodilator of renal preglomerular vessels; blocks 20-HETE-induced vasoconstriction of renal arterioles at 1 µM.
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(±)8-HETE
Cayman Chemical(±)8-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid.
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Lipoxin A5
Cayman ChemicalA 5-series LO derived from EPA; contracts pulmonary parenchymal strips from guinea pig with similar potency to that of LXA4 and LXB4, yet does not exert the vasodilatory effects on aortic smooth muscle exhibited by LXA4 and LXB4.
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20-hydroxy N-Arachidonoyl Taurine
Cayman ChemicalA potential cytochrome P450 metabolite of N-arachidonoyl taurine that may activate TRPV1 and TRPV4.
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(±)8(9)-EET methyl ester
Cayman ChemicalA derivative of (±)8(9)-EET which is stable enough to ship and handle routinely.
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Microcystin-LA
Cayman ChemicalDiffers from the major microcystin variant LR with the substitution of alanine in place of the arginine; inhibits both PP1C and PP2A with an IC50 value of 0.3 nM.
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Latrunculin A
Cayman ChemicalA bioactive macrolide derived from sponges that binds monomeric actin, preventing actin polymerization both in vitro (Kd = 0.2 μM) and in cells (0.5 μM).
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TP53BP1 BRCT domains (human recombinant)
Cayman ChemicalSource: Recombinant human N-terminal GST-tagged protein expressed in E. coli amino acids 1,717-1,972 (N- and C-terminal truncation)
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(±)14(15)-EET-d11
Cayman Chemical(±)14(15)-EET-d11 contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18' ,19, 19' ,20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)14(15)-EET (Item No. 50651) by GC- or LC-MS.
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(±)11(12)-DiHET
Cayman ChemicalThe diol resulting from the sEH opening of (±)11(12)-EET; contracts artery rings with approximately 70% of the magnitude of (±)11(12)-EET.
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15(S)-HETE Ethanolamide
Cayman ChemicalLess potent than AEA (Item No. 90050) at the CB1 receptor (Ki = 600 versus 90 nM); inhibits FAAH.
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6(S)-Lipoxin A4
Cayman ChemicalThe lipoxins are trihydroxy fatty acids containing a 7,9,11,13-conjugated tetraene. LXA4 was first described as a metabolite of 15-HpETE and/or 15-HETE when added in vitro to isolated human leukocytes. The material obtained in this manner consists of at least four distinct isomers: 5(S), 6(S);…
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(±)12-HETE
Cayman Chemical(±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers (Item Nos. 34560 and 34570). It aggregates neutrophils with an EC50…
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KT 5823
Cayman ChemicalA potent, selective inhibitor of PKG (in vitro IC50 = 234 nM); cell-permeable and often used in intact cells to assess the role of PKG in signaling.
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15-OxoETE
Cayman Chemical15-OxoETE is produced by oxidation of the 15-hydroxyl of 15-HETE. Whether this is a major pathway of 15-HETE metabolism is yet to be clearly established.
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11-trans Leukotriene D4
Cayman Chemical11-trans LTD4 is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging…
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(±)14(15)DiHET-d11
Cayman ChemicalAn internal standard for the quantification of (±)14(15)-DiHET by GC- or LC-MS.
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(±)10(11)-EpDPA
Cayman ChemicalA DHA epoxygenase metabolite detected in rat brain and spinal cord, as well as human serum, that acts as a substrate for sEH (Km = 5.1 µM); demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models and potently inhibits angiogenesis and tumor growth in in vitro assays.
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Arachidonic Acid methyl ester 1,2,3,4,5-13C
Cayman ChemicalAn isotopically enriched form of a PUFA standard with carbon-13 occurring at positions 1, 2, 3, 4, and 5; used to study metabolic processes related to arachidonic acid by means of mass spectrometry.
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19(S)-HETE
Cayman ChemicalA major CYP450 metabolite of arachidonic acid that is released from the kidney in response to angiotensin II; a potent vasodilator of renal preglomerular vessels.
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8-iso Prostaglandin F1a-d9
Cayman Chemical8-iso PGF1α-d9 contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of 8-iso PGF1α by GC- or LC-MS.
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trans-EKODE-(E)-Ib
Cayman ChemicalA biologically active peroxidation product of linoleic acid; activates an ARE in neuronal cells and induces the expression of ARE-regulated cytoprotective genes; also stimulates the synthesis of aldosterone and corticosterone in adrenal cells when supplied at 1-5 μM.
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Leukotriene A4-d5 methyl ester
Cayman ChemicalAn internal standard for the quantification of LTA4 methyl ester by GC- or LC-MS.