Cayman Chemical, NEW! Life Science, 50 mg
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N1-Acetylspermine (hydrochloride)
Cayman ChemicalA monoacetylated derivative of spermine (Item No. 18041), an endogenous polyamine synthesized from spermidine (Item No. 14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.
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DuP-697
Cayman ChemicalDuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2. When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the…
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CAY10512
Cayman ChemicalCAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.
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Dabrafenib
Cayman ChemicalA selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50s = 3.2 and 5 nM, respectively); studied in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors.
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GSK-J4 (hydrochloride)
Cayman ChemicalAn ethyl ester prodrug of the JMJD3 selective histone demethylase inhibitor GSK-J1; reduces LPS-induced proinflammatory cytokine production, including that of TNFα (IC50 = 9 µM) in human primary macrophages.
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Cimaterol
Cayman ChemicalA potent agonist of β-adrenergic receptors (pEC50 = 8.13, 8.78, and 6.62 for human β1, β2, and β3, respectively).
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Pyocyanin
Cayman ChemicalActivates the aryl hydrocarbon receptor (Ki = 5.4 µM), inducing the expression of both detoxifying enzymes, resulting in pyocyanin degradation, and cytokines that facilitate the clearance of bacteria; accelerates neutrophil apoptosis, resulting in resolution of acute inflammation.
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Camostat (mesylate)
Cayman ChemicalA trypsin-like protease inhibitor known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein, and thrombin; used in the treatment of chronic pancreatitis and various manifestations of fibrosis.
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Valinomycin
Cayman ChemicalA cyclododecadepsipeptide potassium-selective ionophore antibotic; induces apoptosis in several cell tyes, including CHO cells, by stimulating potassium efflux.
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Wnt-C59
Cayman ChemicalA potent inhibitor of PORCN (IC50 = 74 pM), completely blocking Wnt secretion into culture media; prevents activation of all evaluated Wnt family members; effective in vivo as well as in vitro; blocks the progression of breast cancer while downregulating Wnt/β-catenin pathway target…
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SirReal2
Cayman ChemicalAn aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM) without effect on SIRT1 or SIRT3-6; increases α-tubulin acetylation in HeLa cells.
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RG-108
Cayman ChemicalA non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro) that significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity.
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Pterostilbene
Cayman ChemicalA naturally-occurring dimethyl ether analog of resveratrol; acts as a powerful antioxidant, suppresses the synthesis of PGE2 from LPS-stimulated human peripheral blood mononuclear cells (IC50 = 1.0 μM), and inhibits cell proliferation (IC50 = ~60 μM); evokes effects that…
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TCS PIM-1 1
Cayman ChemicalAn ATP-competitive Pim-1 kinase inhibitor (IC50 = 50 nM) that displays selectivity over the related kinases, Pim-2 and MEK1/2 (IC50s = >20 µM).
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Mecamylamine (hydrochloride)
Cayman ChemicalA noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50s range from 1-7 μM).
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Anhydrotetracycline (hydrochloride)
Cayman ChemicalA powerful effector in both the TetR and revTetR transcriptional regulator systems, binding the Tet repressor 35-fold more strongly than Tet; does not act a general inhibitor of translation and is a poor antibiotic.
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DL-Propargyl Glycine (hydrochloride)
Cayman ChemicalAn irreversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE) (IC50 value of 55 µM).
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Phenamil (methanesulfonate)
Cayman ChemicalA second generation analog of amiloride that inhibits TRPP3-mediated Ca2+-activated (IC50 = 0.14 μM) and ENaC (IC50 = 10 nM); inhibits active sodium transport of human and ovine bronchial epithelial cells (IC50s = 75 and 116 nM, respectively).
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AG-494
Cayman ChemicalAn inhibitor of EGF receptor kinase with an IC50 value of 1 µM in HT-22 cells.
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MAHMA NONOate
Cayman ChemicalMAHMA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1 minute and 3 minutes at 37°C and 22-25°C, respectively, (pH 7.4) to liberate 2 moles of NO per mole of parent compound.
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Paclitaxel
Cayman ChemicalA potent disruptor of microtubules used as a chemotherapeutic compound; inhibits growth of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas with IC50 values ranging from 2.5-7.5 nM; induces mitotic arrest and initiates apoptosis of…
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Suc-Leu-Tyr-AMC
Cayman ChemicalA fluorescent substrate for calpain and papain (excitation max: 360 nm; emission max: 460 nm) that is used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome.
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CAY10444
Cayman ChemicalA selective antagonist of S1P binding to the S1P3 receptor; blocks calcium increase in HeLa cells by about 40% at 10 µM.
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HC-030031
Cayman ChemicalA selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC50 = 6.2 and 5.3 μM, respectively); does not block currents mediated by TRPV1, TRPV3, TRPV4 hERG, or NaV1.2 channels; can be used in cells or delivered to animals orally, by inhalation, or by injection.
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DL-a-Difluoromethylornithine (hydrochloride hydrate)
Cayman ChemicalAn irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis; displays antiangiogenic, cytostatic, and antiparasitic effects.
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m-3M3FBS
Cayman ChemicalAn activator of PLC that stimulates superoxide generation, increase in cytoplasmic calcium, and inositol phosphate formation in human neutrophils when used at a concentration of 15-50 µM; promotes the hydrolysis of phosphatidylinositol bisphosphate by all PLC isoforms.
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CL-82198
Cayman ChemicalA selective inhibitor of human collagenase-3, also known as MMP-13, producing 89% inhibition at 10 µg/ml; used to evaluate the role of MMP-13 in diverse processes.
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Methsuximide
Cayman ChemicalA succinimide that is converted to N-desmethylmethosuximide, a channel blocker that targets low threshold calcium currents; inhibits CYP2C19-mediated metabolism of biguanides; has anticonvulsant properties in clinical trials.
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3'-Sialyllactose (sodium salt)
Cayman ChemicalAn abundant oligosaccharide in the milk of many mammals, including cows and humans, particularly postpartum; avidly binds several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus, in some cases altering viral infectivity.
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Arachidonoyl Cyclopropylamide
Cayman ChemicalA potent, stable, and selective agonist analog of AEA with a Ki value of 2.2 nM at the isolated rat CB1 receptor; 325 times more potent at the CB1 receptor compared with the CB2 receptor; induces hypothermia in mice with the same efficacy as AEA, in spite of its much higher affinity for the CB1…