Cayman Chemical, NEW! Life Science
-
Ku-55933
Cayman ChemicalA potent ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM); sensitizes cells to both ionizing radiation and chemotherapeutic agents; induces senescent breast, lung, and colon carcinoma cells to undergo cell death; inhibits HIV-1 replication in C8166 human T-lymophocyte…
-
Prostaglandin F1ß
Cayman ChemicalPGF1β is the C-9 epimer of PGF1α. It was shown to enhance respiratory rate in experimental animals when administered intravenously.
-
PPOH
Cayman ChemicalArachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway. PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes. PPOH inhibits the…
-
ICI 118551 (hydrochloride)
Cayman ChemicalA potent, selective antagonist of the β2-adrenergic receptor (Ki = 0.7 nM for the β2 receptor, compared with 49.5 and 611 nM for β1 and β3 receptors, respectively); active in vivo and often used to evaluate the actions of adrenergic receptor agonists.
-
Ac-WEHD-AFC
Cayman ChemicalA fluorogenic substrate that can be cleaved specifically by group I caspases.
-
Darapladib
Cayman ChemicalA reversible inhibitor of Lp-PLA2 (IC50 = 0.25 nM) that produces sustained inhibition of plasma Lp-PLA2 activity in humans.
-
SU 9516
Cayman ChemicalA potent inhibitor of several CDKs with selectivity for Cdk2 (IC50s = 22, 40, and 200 nM for Cdk2/cyclin A, Cdk1/cyclin B, and Cdk4/cyclin D1); has anti-proliferative and pro-apoptotic activity in tumor cells.
-
Prostaglandin F2ß
Cayman Chemical9β-hydroxy stereoisomer of PGF2α; much less active than PGF2α in antifertility and bronchoconstrictor activities; exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of PGF2α.
-
CAY10625
Cayman ChemicalAn antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/DIABLO with an IC50 value of 2.2 µM; sensitizes cells to apoptotic stimuli.
-
NSC 348884
Cayman ChemicalA small molecule inhibitor of nucleophosmin dimers that can prevent cell proliferation and induce apoptosis in various cancer cell lines (IC50s = 1.4-4 µM).
-
Olivetol
Cayman ChemicalAn analytical reference standard categorized as a resorcinol; has been found in Cannabis vape cartridges; intended for research and forensic applications
-
Tandutinib
Cayman ChemicalA potent antagonist of the type III receptor tyrosine kinases PDGFRβ, FLT3, and c-Kit (IC50 = 200, 220, and 170 nM, respectively); less potently inhibits CSF-1R (IC50 = 3.4 µM) and does not significantly inhibit other tyrosine or serine/threonine kinases.
-
Methotrexate
Cayman ChemicalAn analog of folic acid and aminopterin that is used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions; induces adenosine release, inhibits the metabolism of folic acid, and blocks key enzymes in the synthesis of purines and pyrimidines…
-
?12-Prostaglandin D2
Cayman ChemicalPGD2 is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically…
-
Tivantinib
Cayman ChemicalA staurosporine derivative that binds to dephosphorylated c-Met kinase and to the colchicine binding site of tubulin; promotes mitotic arrest and apoptosis of various human tumor cell lines (EC50s ranging from 60-600 nM).
-
Eltrombopag
Cayman ChemicalEltrombopag is a small molecule, nonpeptide agonist of the thrombopoietin receptor. It selectively binds to the transmembrane domain of the receptor and stimulates megakaryocytopoiesis in primary human bone marrow cells through the JAK/STAT signaling pathway. Eltrombopag is reported to increase…
-
Letermovir
Cayman ChemicalA small molecule inhibitor of human cytomegalovirus viral replication (EC50 = ~5 nM with a selectivity index >15,000) that targets viral DNA cleavage and packaging.
-
Camptothecin
Cayman ChemicalA cytotoxic, quinoline alkaloid that inhibits the DNA enzyme topoisomerase I (Top I) by binding the Top1-DNA cleavage complex and inducing DNA-strand breaks; has strong anti-tumor activity and induces DNA damage at concentrations as low as 51 nM in whole cells and 12 nM in isolated nuclei in in…
-
17-keto-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
Cayman ChemicalA metabolite of lipoxygenase-mediated oxidation of DPA; activates Nrf2-dependent antioxidant gene expression, acts as a PPARγ agonist (EC50 = ~200 nM), and inhibits pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 µM).
-
-
SR 49059
Cayman ChemicalA selective, nonpeptide antagonist of the vasopressin V1a receptor (Ki = 1.1-6.3 nM in human); inhibits arginine vasopressin-induced human platelet aggregation with an IC50 value of 3.7 nM.
-
5(Z),11(Z),14(Z)-Eicosatrienoic Acid
Cayman Chemical5(Z),11(Z),14(Z)-Eicosatrienoic acid is a PUFA found in various natural sources including maritime pine (Pinus pinaster) seed oil (MPSO), gymnospermae leaves and seeds, and freshwater gastropods. A diet containing MPSO lowered HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was…
-
-
Estrone
Cayman ChemicalEstrone is one of the three naturally occurring estrogens, the others being estradiol and estriol. Estrone is synthesized from androstenedione by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver. Serum…
-
12-OAHSA
Cayman ChemicalA FAHFA in which oleic acid occurs at the 12-position on hydroxy stearic acid.
-
Phenamil (methanesulfonate)
Cayman ChemicalA second generation analog of amiloride that inhibits TRPP3-mediated Ca2+-activated (IC50 = 0.14 μM) and ENaC (IC50 = 10 nM); inhibits active sodium transport of human and ovine bronchial epithelial cells (IC50s = 75 and 116 nM, respectively).
-
Oleic Acid
Cayman ChemicalOleic acid is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Oleic acid contributes about 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets. Oleic acid inhibits collagen-stimulated platelet…
-
Cannabigerovarinic Acid (CRM)
Cayman ChemicalA certified reference material categorized as a phytocannabinoid; intended for research and forensic applications
-
GSK484 (hydrochloride)
Cayman ChemicalA reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme; blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of NETs in both mouse and human neutrophils.
-
Epalrestat
Cayman ChemicalA carboxylic acid-based inhibitor of aldose reductase (IC50 = 0.01-15 μM) that suppresses high glucose-induced proliferation of vascular smooth muscle cells as well as prevents high glucose-induced intracellular NADH/NAD+ increase and membrane-bound protein kinase C activation.
-
25(S)-27-hydroxy Cholesterol
Cayman ChemicalThe less predominant-occurring (~20%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.
-
SB-743921 (hydrochloride)
Cayman ChemicalCAS Number: 940929-33-9 Molecular Formula: C31H33ClN2O3 • HCl Formula Weight: 553.5