Cayman Chemical, 173334-58-2
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Aliskiren (hemifumarate)
Cayman ChemicalA nonpeptide renin inhibitor (IC50 = 0.6 nM) that selectively binds to the S3 sub-pocket of renin, preventing the conversion of angiotensinogen to angiotensin I, thereby blocking eventual conversion to angiotensin II; reduces blood pressure in db/db mice.
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