Unnatural C-15 epimer of Travoprost.

An internal standard for the quantification of DHA by GC- or LC-MS.

A potent inhibitor of HCV infection (EC₅₀ = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC₅₀ = 21.3 µM); displays good pharmacokinetics in mice when delivered intraperitoneally, with preferential liver distribution without…

An alkaloid metabolite of nicotine as well as a major product of its pyrolysis; binds comparably to CYP2A6 and CYP2A13 (Kis = 7.5 and 5.6 µM, respectively), but appears to more effectively inactivate CYP2A6.

Spontaneously hypertensive rats fed a diet which includes γ-tocotrienol show significant reduction of systolic blood pressure and an increase of nitric oxide synthase activity in blood vessels. γ-Tocotrienol at 20 µM induces apoptosis of malignant sympathoadrenal (+SA) murine…

A selective calcium ionophore that mobilizes intracellular calcium stores. It is used as a research tool to raise the intracellular level of calcium, to study calcium transport across biological membranes, and to stimulate the intracellular production of cytokines.

An endocannabinoid analog that does not bind to CB1, CB2, or TRPV1; at 5 mg/kg antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-CBD) in an anesthetized rat blood pressure model; relaxes isolated rat mesenteric arteries and abdominal aorta, and increases the…

An inhibitor of Ras-mediated signaling that inhibits the growth of PANC-1 and U87 tumor cells with IC₅₀ values of 20 and 10 µM, respectively.

A potent and selective agonist of the human PGE2 receptor, EP4 with a Ki value of 0.38 nM and an EC50 value of 0.6 nM; induces thermal hyperalgesia when injected into guinea pig forepaw and increases vasodilation of human pulmonary vein.

Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of sPLA2. The IC₅₀ value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM. In addition to binding to the catalytic site of sPLA2, thioetheramide-PC…

cis-4,10-13,16-Docosatetraenoic acid methyl ester is a long chain PUFA. It is a minor fatty acid component of rat testis lipids. The methyl ester is a neutral, more lipophilic form of the free acid.

A stable analog of TXA2; unlike other TP receptor agonists, it inhibits platelet aggregation (IC₅₀ = 4-5 µM).

PPHP is a substrate for the measurement of peroxidase enzymes. PPHP has been used to quantitate the peroxidase activity of COX-1 and COX-2.

A more lipophilic, stabilized form of HPA.

An EPA-containing MAG amide analog that inhibits the growth of human lung carcinoma A549 cells, producing 98.4% growth inhibition when applied at 3 µM; an analog of EPEA, a natural N-acylethanolamide that impacts aging and inflammation.

An isomer of Vitamin E that has less potent antioxidant properties than α-tocotrienol.

A homolog of EPEA, characterized by the addition of an (R)-α-methyl group at the methylene carbon adjacent to the amide nitrogen.

Oleyloxyethyl phosphorylcholine is an inhibitor of PLA2 with an IC₅₀ value of 6.2 µM for porcine pancreatic PLA2.

Pinolenic acid methyl ester is a neutral, more lipophilic form of the free acid.

A homolog of EPEA, characterized by the addition of an (S)-α-methyl group at the methylene carbon adjacent to the amide nitrogen.

Oxidized LDL (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the…

A prodrug formulation of HPA which may be useful in various biochemical studies and as a reference standard in analytical work.

An internal standard for the quantification of OEA by GC- or LC-MS.

A form of oleic acid with an ω-terminal alkyne for use in click chemistry reactions.

A fluorescently-tagged probe consisting of C-10 ceramide with an AV group attached to the end of the acyl chain.

Diets high in fiber contain plant lignan species that may be directly responsible for some observed health benefits of these diets. Enterolactone is an enterobacterial breakdown product of plant lignans that is absorbed and can be measured in human serum. Enterolactone and other ligans and…

A lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α.

Prostaglandin E2 (PGE2) is the major eicosanoid product of cyclooxygenase-1 and 2 in epithelial cells, leukocytes, reproductive tissues, and many others. PGE2 contracts smooth muscle, protects the gastric mucosa, modulates immune function, and regulates fertility and implantation. PGE2 acts through…

ω-3 Arachidonic acid is a rare PUFA found in trace amounts in dietary sources. ω-3 Fatty acids are now known to be essential for infant growth and development and protect against heart disease, thrombosis, hypertension, and inflammatory and autoimmune disorders. In human platelet…

A hydrophobic derivative of deoxynojirimycin that potently inhibits β-glucosidase 2 (IC50 = 0.3 nM), less potently antagonizes glucosylceramide synthase (IC50 = 25 nM), but only poorly inhibits other GCase isoforms; suppresses hapten-induced colitis, enhances insulin sensitivity, and induces…

A monohydroperoxy PUFA produced by the action of 15-LO on α-linolenic acid.

An internal standard for the quantification of DHA ethyl ester by GC- or LC-MS.