Cayman Chemical, 5 mg, Biologically Active Small Molecules, 1097917-15-1

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  • Cayman Chemical

    An ATP-competitive, second-generation ALK inhibitor (IC50 = 3.5 nM) that also inhibits ROS (IC50 = 8.9 nM) and ACK (IC50 = 5.8 nM); demonstrates antitumor activity in xenograft mouse models and has been shown to overcome crizotinib resistance in non-small cell lung cancer.