A fluorogenic substrate of palmitoyl-protein thioesterase.

A chromogenic substrate for endoglucanases and cellobiohydrolases.

A DHA epoxygenase metabolite detected in rat brain and spinal cord, as well as human serum, that acts as a substrate for sEH (Km = 5.1 µM); demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models and potently inhibits angiogenesis and tumor growth in in vitro assays.

An internal standard for the quantification of 17β-estradiol by GC- or LC-MS.

A natural type B trichothecene produced by certain species of the fungus Fusarium; inhibits protein biosynthesis, binds to peptidyl transferase, and inhibits the synthesis of RNA and DNA; passes the blood-brain barrier at different rates in different animals.

An internal standard for the quantification of (2S)-octyl-α-hydroxyglutarate by GC- or LC-MS.

An analytical reference material that is structurally similar to known phytocannabinoids; precursor of THCVA in Cannabis; intended for research and forensic applications ,

11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM. 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2. 11β-PGE2 inhibits PGE2 binding to the…

A synthetic thyroid hormone mimetic that lowers total and LDL cholesterol up to 40% when administered to humans at a dose of 50-200 µg once daily for 14 days; stimulates cholesterol catabolism to bile acids without affecting cholesterol synthesis.

A PKCα and PKCβ1 inhibitor with IC₅₀ values of 2.3 and 6.2 nM, respectively; also inhibits the checkpoint kinases Chk1/2 and abrogates DNA damage-induced cell cycle arrest, leading to cytotoxicity in p53 mutant tumor cells.

A metabolite of estradiol 3-sulfate that has been modified by a UDP-glucuronosyltransferase; enhances utilization by anion transporters, most commonly leading to excretion in urine and bile.

8-iso-17-phenyl PGF2β is an isomer of bimatoprost (free acid) that is epimerized at the 8 and 9 positions. There are no published reports on the biological activity of 8-iso-17-phenyl PGF2β.

A hepatic metabolite of zearalenone that is a less potent agonist of estrogen receptors than the parent compound.

Steroisomer of PGF1α with both C-9 and C-11 hydroxyls inverted.

A dietary carotenoid present in the macula region of the eye; high dietary intake correlates with reduced risk of age-related macular degeneration.

A regioisomeric resveratrol metabolite that may be used as a reference standard for accurate determination of the metabolic profile of resveratrol.

An activator of sGC that binds to a regulatory site, resulting in activation in an NO-independent manner (Kd = 3.2 nM); reduces hypertension, limits cardiomyocyte hypertrophy, protects against ischemia/reperfusion injury, and reduces morbidity and mortality in response to endotoxic shock.

An internal standard for the quantification of trans-resveratrol by GC- or LC-MS.

11β-PGF2α-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 11β-PGF2α by GC- or LC-MS.

A toxin produced by cyanobacteria that inhibits the catalytic activity of protein phosphatases PP1C, PP1γ, and PP2A with Ki values of 0.15, 0.24, and 0.018 nM, respectively.

A synthetic peptide corresponding to an amino acid sequence found in the amino terminal C2 domain of most mammalian forms of PKC?; selectively and reversibly inhibits the translocation of PKC? to intracellular membranes, blocking activation.

An internal standard for the quantification of cannabidiol by GC- or LC-MS; intended for research and forensic applications.

An irreversible inhibitor of BMX (IC₅₀ = 8 nM) and BTK (IC₅₀ = 10.4 nM); inhibits the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells (GI₅₀ = 25 nM), as well as RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI₅₀s = 2.54, 4.38,…

One of four major analogs in the enniatin complex that has been shown to moderately inhibit ACAT activity in rat liver microsomes (IC₅₀ = 22 µM); demonstrates anthelmintic properties against N. brasiliensis, T. spiralis, and H. spumosa.

A cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis in glioma stem cells (IC₅₀ = 31 µM); abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.

A potent peptide agonist of the GLP-1 receptor (Ki = 136 pM); stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells, supporting efficacy in type 2 diabetes; protects hippocampal neurons against glutamate-induced apoptosis.

An inactive control for the selective PAD4 inhibitors, GSK484 and GSK199 (IC₅₀s >100 µM).

A synthetic analog of natural PIP3 with C6:0 fatty acids at the sn-1 and sn-2 positions; features the same inositol and diacylglycerol stereochemistry as the natural compound; the short fatty acid chains give it higher solubility in aqueous media, as compared to naturally-occurring PIP3.

A naturally occurring metabolite of bile acid that is produced by the conjugation of cholic acid and sulfate, predominantly in the liver and gut.

An internal standard for the quantification of creatinine by GC- or LC-MS.

A DHA epoxygenase metabolite found in rat brain and spinal cord that acts as a preferred substrate for sEH (Km = 3.2 µM); demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models and potently inhibits angiogenesis and tumor growth in in vitro assays.

13(S)-HpODE is produced by the oxidation of linoleic acid by LO-1 in many plants including soybean, flaxseed, apples, and tea leaves, and by 15-LO in mammals. In plants, 13(S)-HpODE is the preferred substrate for the garlic bulb divinyl ether synthase. In mammalian tissues, 13(S)-HpODE is generally…