Cayman Chemical, Bottle, Glass, Clear, 50 µg
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15(S)-HETE-d8
Cayman Chemical15(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 15(S)-HETE by GC- or LC-MS.
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5-iPF2a-VI
Cayman ChemicalIsoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes. iPF2α-VI is one of dozens of possible stereo- and…
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KT 5823
Cayman ChemicalA potent, selective inhibitor of PKG (in vitro IC50 = 234 nM); cell-permeable and often used in intact cells to assess the role of PKG in signaling.
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8(S)-HETrE
Cayman Chemical8(S)-HETrE is a monohydroxy PUFA produced by rabbit neutrophil lipoxygenase when DGLA is used as a substrate. Although the biological activities of 8(S)-HETrE have not been well characterized, it is expected to behave similarly to 8(S)-HETE.
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(±)11(12)-EET-d11
Cayman ChemicalAn internal standard for the quantification of ±11(12)-EET by GC- or LC-MS.
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(±)12-HpETE
Cayman Chemical(±)12-HpETE is one of the six monohydroperoxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid (Item No. 90010) and consists of an equal mixture of the R and S isomers. Reduction of the hydroperoxide yields the more stable hydroxyl fatty acid (±)12-HETE (Item…
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13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4
Cayman ChemicalAn internal standard for quantification of 13,14-dihydro-15 (R,S)-hydroxy-16,16-difluoro-Prostaglandin E1, a metabolite of a bicyclic PGE1 derivative used in the treatment of chronic constipation, by GC- or LC-mass spectrometry (MS).
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PPARd (human recombinant)
Cayman ChemicalSource: recombinant protein expressed in Sf21 cells Mr: 54 kDa PPARs are members of the nuclear receptor family of ligand activated transcription factors that heterodimerize with retinoic acid like receptors, regulating gene expression and differentiation. PPARδ is a mediator of diverse…
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(±)13(14)-EpDPA
Cayman ChemicalA DHA epoxygenase metabolite found in rat brain and spinal cord that acts as a preferred substrate for sEH (Km = 3.2 µM); demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models and potently inhibits angiogenesis and tumor growth in in vitro assays.
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Microcystin-RR
Cayman ChemicalA toxin produced by cyanobacteria that inhibits the catalytic activity of protein phosphatases PP1C, PP1γ, and PP2A with Ki values of 0.15, 0.24, and 0.018 nM, respectively.
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Arachidonic Acid methyl ester 1,2,3,4,5-13C
Cayman ChemicalAn isotopically enriched form of a PUFA standard with carbon-13 occurring at positions 1, 2, 3, 4, and 5; used to study metabolic processes related to arachidonic acid by means of mass spectrometry.
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(±)11(12)-EpETE
Cayman ChemicalAn epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo; its effects of remain to be determined.
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TP53BP1 BRCT domains (human recombinant)
Cayman ChemicalSource: Recombinant human N-terminal GST-tagged protein expressed in E. coli amino acids 1,717-1,972 (N- and C-terminal truncation)
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Nodularin
Cayman ChemicalA hepatotoxic monocylic pentapeptide that acts as a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively.
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19(R)-HETE
Cayman ChemicalA major CYP450 metabolite of arachidonic acid that is released from the kidney in response to angiotensin II; a potent vasodilator of renal preglomerular vessels; blocks 20-HETE-induced vasoconstriction of renal arterioles at 1 µM.
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(±)14(15)-EET-d11
Cayman Chemical(±)14(15)-EET-d11 contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18' ,19, 19' ,20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)14(15)-EET (Item No. 50651) by GC- or LC-MS.
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2,3-dinor-11ß-Prostaglandin F2a
Cayman ChemicalKey urinary metabolite of PGD2; represents approximately 1% and 4% of the infused radiolabeled dose in monkeys and humans, respectively.
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11ß-13,14-dihydro-15-keto Prostaglandin F2a
Cayman ChemicalA metabolite of PGD2 via the 15-hydroxy PGDH pathway.
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15(S)-HETE Ethanolamide
Cayman ChemicalLess potent than AEA (Item No. 90050) at the CB1 receptor (Ki = 600 versus 90 nM); inhibits FAAH.
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(±)8(9)-EET methyl ester
Cayman ChemicalA derivative of (±)8(9)-EET which is stable enough to ship and handle routinely.
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(±)14(15)-EpEDE methyl ester
Cayman ChemicalAn analog of (±)14(15)-EpEDE with greater lipid solubility than the free base.
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tetranor-PGAM
Cayman ChemicalA dehydration product of tetranor-PGEM that can be measured as a surrogate for tetranor-PGEM levels in urine.
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Lipoxin B4
Cayman ChemicalA positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes; inhibits PMV migration stimulated by LTB4 at a concentration of 10-7 M and inhibits LTB4-induced adhesion of PMNs with an IC50 value of ~3 x 10-10 M.
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tetranor-12(S)-HETE
Cayman ChemicalMajor β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE
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Lactacystin
Cayman ChemicalA microbial metabolite isolated from Streptomyces that is widely used as a selective inhibitor of the 20S proteasome.
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15(R)-Lipoxin A4
Cayman ChemicalAn aspirin-triggered lipoxin that inhibits LTB4-induced chemotaxis, adherence, and transmigration of the neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.
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(±)11(12)-DiHET
Cayman ChemicalThe diol resulting from the sEH opening of (±)11(12)-EET; contracts artery rings with approximately 70% of the magnitude of (±)11(12)-EET.
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Tafluprost-d4
Cayman ChemicalContains four deuterium atoms at the 3', 3', 4', and 4' positions; is intended for use as an internal standard for the quantification of tafluprost by GC-or LC-mass spectrometry.
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(±)8-HETE
Cayman Chemical(±)8-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid.
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GDF11 (human recombinant)
Cayman ChemicalSource: Recombinant protein expressed in E. coli MW: 12.5 kDa
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13,14-dihydro-19(R)-hydroxy Prostaglandin E1
Cayman Chemical13,14-dihydro-19(R)-hydroxy PGE1 is the theoretical metabolite of 13,14-dihydro PGE1 by ω-1 hydroxylase. There are no known reports on its biosynthesis or biological activity.
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Docosahexaenoic Acid-d5
Cayman ChemicalAn internal standard for the quantification of DHA by GC- or LC-MS.
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